Replication and transformation functions of in vitro-generated simian virus 40 large T antigen mutants
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Identification of a region of simian virus 40 large T antigen required for cell transformationFunctional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen.T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisAnalyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replicationA simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence.Mutational analysis of simian virus 40 small-t antigen.A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.A specific signature of Merkel cell polyomavirus persistence in human cancer cells.Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity.The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism.Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations.The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen.Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein.Conformational rearrangements of SV40 large T antigen during early replication events.
P2860
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P2860
Replication and transformation functions of in vitro-generated simian virus 40 large T antigen mutants
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Replication and transformation ...... rus 40 large T antigen mutants
@en
type
label
Replication and transformation ...... rus 40 large T antigen mutants
@en
prefLabel
Replication and transformation ...... rus 40 large T antigen mutants
@en
P2093
P2860
P1433
P1476
Replication and transformation ...... rus 40 large T antigen mutants
@en
P2093
J E Rutila
M J Imperiale
W W Brockman
P2860
P304
P407
P577
1986-05-01T00:00:00Z