Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. - Wikidata - wikimedia - TriplyDB

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

http://www.wikidata.org/entity/Q36889731

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JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications Protein tyrosine phosphatases as wardens of STAT signaling Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia STAT5 in hematopoietic stem cell biology and transplantation Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia Myelodysplastic Syndromes Diagnosis: What Is the Role of Molecular Testing?How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5 Large granular lymphocytic leukemia. Current diagnostic and therapeutic approaches and novel treatment options.Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.The pathogenesis and treatment of large granular lymphocyte leukemia The spectrum of chronic CD8+ T-cell expansions: clinical features in 14 patients.Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells.Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia.Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia.Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 study Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality.The 2016 revision of the World Health Organization classification of lymphoid neoplasms.Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes.The genetic basis of myelodysplasia and its clinical relevance Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation.Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.Therapeutic targeting of the Jak/STAT pathway.Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy.Disease-specific mutations in mature lymphoid neoplasms: recent advances.Molecular pathways: interleukin-15 signaling in health and in cancer.The JAK-STAT pathway: impact on human disease and therapeutic intervention Differential gene expression of the key signalling pathway in para-carcinoma, carcinoma and relapse human pancreatic cancer.Molecular Pathogenesis of Peripheral T Cell Lymphoma.Mature T-cell leukemias: Molecular and Clinical Aspects.Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization.Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function.

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Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

http://www.wikidata.org/entity/Q36889731

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

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2013年论文

@zh-cn

name

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

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type

label

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

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prefLabel

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

@en

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Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

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Andres Jerez

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Andy Awwad

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Arjan J van Adrichem

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Caroline Heckman

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Dan Zhang

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Hanna L M Rajala

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Heikki Kuusanmäki

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Jaroslaw P Maciejewski

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Michael J Clemente

http://www.w3.org/2001/XMLSchema#string

Sonja Lagström

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P2860

Chipster: user-friendly analysis software for microarray and other high-throughput data

The SWISS-MODEL Repository and associated resources

Three-dimensional structure of the Stat3beta homodimer bound to DNA

Somatic STAT3 mutations in large granular lymphocytic leukemia

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

Normalization of cDNA microarray data

Growth hormone insensitivity and severe short stature in siblings: a novel mutation at the exon 13-intron 13 junction of the STAT5b gene

Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

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4541-4550

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Olli-Pekka Kallioniemi

Krister Wennerberg

Emma I Andersson

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