Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1 - Wikidata - wikimedia - TriplyDB

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

http://www.wikidata.org/entity/Q36889964

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Role of Nrf2 in oxidative stress and toxicity DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation N-acetylcysteine in COPD: why, how, and when?Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Sirtuin 1 and aging theory for chronic obstructive pulmonary disease Oxidative stress and free radicals in COPD--implications and relevance for treatment Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Stress-activated cap'n'collar transcription factors in aging and human disease Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild-moderate ex-smoker COPD patients with persistent oxidative stress Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation Nrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzae Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation Nrf2 is required for normal postnatal bone acquisition in mice Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian Cancer Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression.Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs.DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.NFE2L2 polymorphisms, mortality, and metabolism in the general population.Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice Large-scale proteomics differentiates cholesteatoma from surrounding tissues and identifies novel proteins related to the pathogenesis.Human alveolar epithelial cell injury induced by cigarette smoke Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.Decreased DJ-1 leads to impaired Nrf2-regulated antioxidant defense and increased UV-A-induced apoptosis in corneal endothelial cells.Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction.

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Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

http://www.wikidata.org/entity/Q36889964

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Decline in NRF2-regulated anti ...... f its positive regulator, DJ-1

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RCCM.200803-380OC

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American Journal of Respiratory and Critical Care Medicine

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Decline in NRF2-regulated anti ...... f its positive regulator, DJ-1

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Ana Navas-Acien

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Andrew Sandford

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Anju Singh

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Deepti Malhotra

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James Hogg

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Linan Chen

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Mark Elliott

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Peter Pare

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Rajesh Thimmulappa

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Rubin M Tuder

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P2860

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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592-604

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10.1164/RCCM.200803-380OC

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6

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178

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2008-06-12T00:00:00Z

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5299368

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18556627

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chronic obstructive pulmonary disease

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2542433

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