Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants.
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Identification of a region of simian virus 40 large T antigen required for cell transformationSimian virus Large T antigen interacts with the N-terminal domain of the 70 kD subunit of Replication Protein A in the same mode as multiple DNA damage response factorsSimian virus 40 large T antigen: the puzzle, the pieces, and the emerging pictureA deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen.T antigen and template requirements for SV40 DNA replication in vitro.The abnormal location of cytoplasmic SV40 large T is not caused by failure to bind to DNA or to p53.Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens.Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replicationCommon and unique features of T antigens encoded by the polyomavirus groupAnalysis of a large-T-antigen variant expressed in simian virus 40-transformed mouse cell line mKS-A.Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen.Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation.Helicase, DNA-binding, and immunological properties of replication-defective simian virus 40 mutant T antigens.Activation of ATPase activity of simian virus 40 large T antigen by the covalent affinity analog of ATP, fluorosulfonylbenzoyl 5'-adenosineSimian virus 40 T antigen alters the binding characteristics of specific simian DNA-binding factorsBinding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigenSpecific mutation of a regulatory site within the ATP-binding region of simian virus 40 large T antigenThe T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence.Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.Intrachromosomal recombination mediated by papovavirus large T antigens.Simian virus 40 DNA replication correlates with expression of a particular subclass of T antigen in a human glial cell lineThe ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53.Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replicationSimian virus 40 host range/helper function mutations cause multiple defects in viral late gene expression.Constitutive expression of simian virus 40 large T antigen in monkey cells activates their capacity to support polyomavirus replicationSimian virus 40 origin DNA-binding domain on large T antigen.Properties of the simian virus 40 (SV40) large T antigens encoded by SV40 mutants with deletions in gene A.Expression of 100,000-Mr simian virus 40 (SV40) tumor antigen in mouse fibroblasts transfected with replication-defective SV40 genomesReplication and transformation functions of in vitro-generated simian virus 40 large T antigen mutantsConstruction and characterization of hybrid polyomavirus genomes.Characterization of simian virus 40 large T antigen by using different monoclonal antibodies: T-p53 complexes are preferentially ATPase active and adenylylated.trans-dominant defective mutants of simian virus 40 T antigen.T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication.Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation.A second domain of simian virus 40 T antigen in which mutations can alter the cellular localization of the antigenStudies on the origin-specific DNA-binding domain of simian virus 40 large T antigenFormation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1.
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P2860
Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Genetic and biochemical analys ...... us 40 large T antigen mutants.
@en
type
label
Genetic and biochemical analys ...... us 40 large T antigen mutants.
@en
prefLabel
Genetic and biochemical analys ...... us 40 large T antigen mutants.
@en
P2860
P1433
P1476
Genetic and biochemical analys ...... us 40 large T antigen mutants.
@en
P2093
P2860
P304
P407
P577
1985-01-01T00:00:00Z