Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.
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Ancient mtDNA genetic variants modulate mtDNA transcription and replicationAllotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Mitochondrial cytochrome c oxidase deficiencyLeber hereditary optic neuropathy: current perspectivesPromising and delivering gene therapies for vision lossA comprehensive review of retinal gene therapyIdebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathySuccessful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal modelA neurodegenerative perspective on mitochondrial optic neuropathiesBiology and therapy of inherited retinal degenerative disease: insights from mouse modelsGene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.Treatment strategies for inherited optic neuropathies: past, present and futureMitochondrial disorders and the eye.Medical management of hereditary optic neuropathies.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.The optic nerve: a "mito-window" on mitochondrial neurodegenerationThe neuro-ophthalmology of mitochondrial diseaseTrial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial.Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.Vector platforms for gene therapy of inherited retinopathies.LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutantEfficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual systemLHON: Mitochondrial Mutations and More.Leber Hereditary Optic Neuropathy - Therapeutic Challenges and Early Promise.Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.Animal models of human mitochondrial DNA mutations.Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Disorders of the optic nerve in mitochondrial cytopathies: new ideas on pathogenesis and therapeutic targets.Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in miceInduction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic NeuropathyLet There Be Light: Gene and Cell Therapy for Blindness.Emerging therapies for mitochondrial disorders.Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice.Subcellular targeting: a new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet.Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results.
P2860
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P2860
Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Optimized allotopic expression ...... of mitochondrial dysfunction.
@en
type
label
Optimized allotopic expression ...... of mitochondrial dysfunction.
@en
prefLabel
Optimized allotopic expression ...... of mitochondrial dysfunction.
@en
P2093
P2860
P1476
Optimized allotopic expression ...... of mitochondrial dysfunction.
@en
P2093
Aicha Bouaita
Jose-Alain Sahel
Manuel Simonutti
Marisol Corral-Debrinski
Sami Ellouze
Sébastien Augustin
Valérie Forster
P2860
P304
P356
10.1016/J.AJHG.2008.08.013
P407
P577
2008-09-04T00:00:00Z