Focal adhesion kinase and p53 signaling in cancer cells.
about
FAK and paxillin, two potential targets in pancreatic cancerFAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.Discovery of novel focal adhesion kinase inhibitors using a hybrid protocol of virtual screening approach based on multicomplex-based pharmacophore and molecular dockingEvolving Therapies and FAK Inhibitors for the Treatment of CancerInteractions of the protein-tyrosine phosphatase-α with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts.Integrin signaling through FAK in the regulation of mammary stem cells and breast cancerFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisFAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeuticsMammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer.An evaluation of the anti-angiogenic effect of the Korean medicinal formula "Sa-mi-yeon-geon-tang" in vitro and in ovo.Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivoPharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo.The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cellsA small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activitiesA novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.Distinct FAK activities determine progenitor and mammary stem cell characteristics.Focal adhesion kinase versus p53: apoptosis or survival?Targeting the p53 pathway.Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy.Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.FAK overexpression and p53 mutations are highly correlated in human breast cancer.Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices.The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance.Focal adhesion kinase and p53 signal transduction pathways in cancer.Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.FAK and p53 protein interactions.Targeting FAK in human cancer: from finding to first clinical trials.Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex.Anti-carcinogenic activity of anandamide on human glioma in vitro and in vivo.Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).Multiplexed high content screening reveals that cigarette smoke condensate-altered cell signaling pathways are accentuated through FAK inhibition in human bronchial cells.FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genesExploring the interaction between human focal adhesion kinase and inhibitors: a molecular dynamic simulation and free energy calculations.
P2860
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P2860
Focal adhesion kinase and p53 signaling in cancer cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Focal adhesion kinase and p53 signaling in cancer cells.
@en
type
label
Focal adhesion kinase and p53 signaling in cancer cells.
@en
prefLabel
Focal adhesion kinase and p53 signaling in cancer cells.
@en
P1476
Focal adhesion kinase and p53 signaling in cancer cells.
@en
P2093
Vita M Golubovskaya
William G Cance
P304
P356
10.1016/S0074-7696(07)63003-4
P577
2007-01-01T00:00:00Z