Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.
about
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesisSolubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminaseProliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survivalMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesProliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovariesThe Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ TransplantationDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationSimultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathwaysProteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cellsThe RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombinationATAD5 deficiency decreases B cell division and Igh recombinationThe Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Histone H2A and H2B are monoubiquitinated at AID-targeted loci.Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.AID and somatic hypermutation.Msh6 protects mature B cells from lymphoma by preserving genomic stability.An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain.Mismatch-mediated error prone repair at the immunoglobulin genes.DNA polymerase ζ generates tandem mutations in immunoglobulin variable regionsHLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligaseDoes DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerasesMSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat dietH3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.Identification of host cellular proteins that interact with the M protein of a highly pathogenic porcine reproductive and respiratory syndrome virus vaccine strain.Roles of sequential ubiquitination of PCNA in DNA-damage tolerance.Translesion DNA synthesis and mutagenesis in eukaryotesAID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity.Meiotic Recombination: The Essence of Heredity.The gene expression profiling of hepatocellular carcinoma by a network analysis approach shows a dominance of intrinsically disordered proteins (IDPs) between hub nodes.PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.Target validation and structure-activity analysis of a series of novel PCNA inhibitors
P2860
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P2860
Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.
@en
type
label
Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.
@en
prefLabel
Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.
@en
P2093
P2860
P356
P1476
Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.
@en
P2093
Aviv Bergman
Chunfang Zhao
Elena Avdievich
Fei Li Kuang
Jonathan U Peled
Matthew D Scharff
Paula E Cohen
Sergio Roa
Thomas Maccarthy
P2860
P304
16248-16253
P356
10.1073/PNAS.0808182105
P407
P577
2008-10-14T00:00:00Z