Polyglutamine neurodegeneration: protein misfolding revisited.
about
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3New insights into repeat instability: role of RNA•DNA hybridsFour decades of neurodegenerative disease research: how far we have come!Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of diseaseThe unstable repeats--three evolving faces of neurological diseaseHuntington's disease: underlying molecular mechanisms and emerging conceptsThe human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegenerationThe SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasisSecondary Structure of Huntingtin Amino-Terminal RegionDisease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact StructureMotor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive ReviewRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosisAmyloid-associated activity contributes to the severity and toxicity of a prion phenotypeCo-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapyUbe2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIPAmyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host proteinStructure prediction of polyglutamine disease proteins: comparison of methods.Trinucleotide repeats: a structural perspectiveElongation kinetics of polyglutamine peptide fibrils: a quartz crystal microbalance with dissipation study.Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo.Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defectsFormation and toxicity of soluble polyglutamine oligomers in living cells.Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesThe carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.Transcriptional activation of REST by Sp1 in Huntington's disease modelsEndoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapyOligonucleotide-based strategies to combat polyglutamine diseases.Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus.Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansionA major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.Heat shock protein 70 (hsp70) as an emerging drug target.Heat shock protein 90 in neurodegenerative diseasesPOLG1 polyglutamine tract variants associated with Parkinson's disease.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila eyes
P2860
Q24318431-B9F53475-497B-4E69-8275-F0AD4EFC39D0Q24621985-49491EDF-2E95-4357-956E-73714E13B0EAQ24645662-CDAF9274-178C-4C15-BB9D-C045E06A1E49Q26764958-9C737C24-389E-4630-9426-A132A8DDA3B8Q27025923-36687C41-7908-49EA-9F28-6B0D1B105199Q27026255-7CBFF991-029F-404C-AE46-C433E21BE86DQ27312345-3B090279-D441-4E92-8D6D-DCC7D242ABE9Q27335565-1DD6F8B4-F3E6-45B0-80D6-F7710C95819EQ27657408-D3A3A5A6-B5C6-4201-B4F4-C47272E8B783Q27677065-7EA0AC0A-AF76-410B-85B8-94CBC20F9551Q28076174-5C728F3A-F695-499A-9E05-E999290E3824Q28082520-B12F2682-FBDE-4697-9349-F501DB0D6270Q28243882-9CA85D74-8DF7-4B03-A691-0D0853A5F9EEQ28285156-44784C1A-9C58-4DBA-AE0E-2597DEAEFBC5Q28593538-94B77742-D402-4DB4-974D-9E2983EED8F9Q28731292-6B8C86A8-88DD-4695-9B30-C1213A829D7BQ30365315-592FD5B0-7C12-4E15-82CB-0EA16495949EQ30432441-69E88573-F467-443E-B30C-E7847DC50C87Q30450982-D15997EF-B054-4F5E-82F7-E3FDE2745BCBQ30523072-22EAE2BB-89B6-40D5-988E-3593F47AEEC7Q30663550-E0C04872-853F-4732-B736-DFB8ABC90F0FQ30994681-C64BACB8-A2EA-44C1-AFEE-315317A4B950Q33594383-6E335624-FB5F-4BAF-82D8-692D3122E2AFQ33607305-36FD1981-453F-42DE-899A-71E8F0D323C0Q33639492-44BF4364-4751-46EF-AAD2-24D114E35505Q33692255-8B697693-BE00-4E8C-8AA2-0D9BD6782448Q33739563-974EA770-3016-470E-A434-086F37AC97BBQ33778522-3812E7F3-A61E-4684-A495-055C733B64B3Q33784026-3E1553B3-8AAB-44D6-B8D0-224A16A2E1EBQ33791247-6DE9DAD5-CE6B-4EC9-829E-CA9420827AF5Q33815559-06E629D4-8AFA-4DD4-9C37-1C5E9B9EB6D9Q33878156-7724DD28-F94B-4307-A40F-6CF0A4994AF0Q33886685-27BB5C39-0B13-455E-9B87-F68B5633344CQ33956906-199A8F13-7816-4B37-96B6-FA5636AA4013Q33961301-631E6EFC-07C0-4EE4-904C-3E2B46F67EF4Q34002331-3BEB8843-D8E7-4E37-9232-55973520BB65Q34063163-69BC8303-E5E8-4DE4-976F-36D64DA58538Q34066654-D312E903-A815-4429-AA49-E2EF48D3AC9AQ34074385-454F1DBF-AB2A-4D97-8238-387055A7FCC1Q34088872-0D58E56C-FB70-43B6-ADC1-89C1EAE6C05D
P2860
Polyglutamine neurodegeneration: protein misfolding revisited.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Polyglutamine neurodegeneration: protein misfolding revisited.
@en
type
label
Polyglutamine neurodegeneration: protein misfolding revisited.
@en
prefLabel
Polyglutamine neurodegeneration: protein misfolding revisited.
@en
P2860
P1476
Polyglutamine neurodegeneration: protein misfolding revisited
@en
P2093
Henry L Paulson
P2860
P304
P356
10.1016/J.TINS.2008.07.004
P577
2008-09-06T00:00:00Z