Misregulated RNA processing in amyotrophic lateral sclerosis.
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FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitmentGenotype-phenotype correlations of amyotrophic lateral sclerosisGolgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport VesiclesA comprehensive review of amyotrophic lateral sclerosisRNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal FunctionsConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe neurogenetics of alternative splicingALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the diseaseAre aberrant phase transitions a driver of cellular aging?RNA seeds higher-order assembly of FUS protein.A random set scoring model for prioritization of disease candidate genes using protein complexes and data-mining of GeneRIF, OMIM and PubMed records.Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.Harnessing natural sequence variation to dissect posttranscriptional regulatory networks in yeastConcise review: Stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the futurePur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders.Targeting RNA binding proteins involved in neurodegeneration.Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functionsLoss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.Intermediate CAG repeat expansion in the ATXN2 gene is a unique genetic risk factor for ALS--a systematic review and meta-analysis of observational studies.Comparison of dendritic calcium transients in juvenile wild type and SOD1(G93A) mouse lumbar motoneurons.ALS mutations in TLS/FUS disrupt target gene expression.The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila.RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutationsDivergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosisDistinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.Genetics of amyotrophic lateral sclerosis: an update.C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles.The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons.Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS.Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND).Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons.A dynamic alternative splicing program regulates gene expression during terminal erythropoiesisThe spliceosome: disorder and dynamics defined.Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma.Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases.RNA metabolism in ALS: when normal processes become pathological.
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P2860
Misregulated RNA processing in amyotrophic lateral sclerosis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Misregulated RNA processing in amyotrophic lateral sclerosis.
@en
type
label
Misregulated RNA processing in amyotrophic lateral sclerosis.
@en
prefLabel
Misregulated RNA processing in amyotrophic lateral sclerosis.
@en
P2093
P2860
P1433
P1476
Misregulated RNA processing in amyotrophic lateral sclerosis.
@en
P2093
C Frank Bennett
Don W Cleveland
Gene W Yeo
Kasey R Hutt
Magdalini Polymenidou
P2860
P356
10.1016/J.BRAINRES.2012.02.059
P407
P577
2012-03-03T00:00:00Z