A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients
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Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitorThe IFITM proteins inhibit HIV-1 infectionHow to Define the Latent Reservoir: Tools of the TradeNew assays for monitoring residual HIV burden in effectively treated individualsEpisomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failureElite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes.CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cellsQuantitative PCR used to assess HIV-1 integration and 2-LTR circle formation in human macrophages, peripheral blood lymphocytes and a CD4+ cell lineA real time PCR platform for the simultaneous quantification of total and extrachromosomal HIV DNA forms in blood of HIV-1 infected patientsCross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies.Comparative analysis of measures of viral reservoirs in HIV-1 eradication studiesRapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assayA Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected IndividualsThe Molecular Characterization of Intestinal Explant HIV Infection Using Polymerase Chain Reaction-Based Techniques.Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs.Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trialsSUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV.How to best measure HIV reservoirs?Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR.Finding a cure for human immunodeficiency virus-1 infection.Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications.Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.Underlying mechanisms of HIV-1 latency.The viral protein Tat can inhibit the establishment of HIV-1 latency.Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef.Patients on HAART often have an excess of unintegrated HIV DNA: implications for monitoring reservoirs.Stage-dependent inhibition of HIV-1 replication by antiretroviral drugs in cell culture.Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells.Quantification of the Latent HIV-1 Reservoir Using Ultra Deep Sequencing and Primer ID in a Viral Outgrowth Assay.Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells.Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.The Use of Ultra-Sensitive Molecular Assays in HIV Cure-Related Research.Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.Assays to Measure Latency, Reservoirs, and Reactivation.Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained.EFFECT OF SHORT-TERM ART INTERRUPTION ON LEVELS OF INTEGRATED HIV DNA.Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles
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A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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A more precise HIV integration ...... DNA in HAART treated patients
@en
A more precise HIV integration ...... DNA in HAART treated patients.
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type
label
A more precise HIV integration ...... DNA in HAART treated patients
@en
A more precise HIV integration ...... DNA in HAART treated patients.
@nl
prefLabel
A more precise HIV integration ...... DNA in HAART treated patients
@en
A more precise HIV integration ...... DNA in HAART treated patients.
@nl
P2093
P2860
P921
P1433
P1476
A more precise HIV integration ...... DNA in HAART treated patients
@en
P2093
Bruce L Levine
Clifford Baytop
Jianqing J Yu
Jihong Dai
Megan K Liszewski
Te Lang Wu
Theodore Theodosopoulos
Una O'Doherty
P2860
P356
10.1016/J.VIROL.2008.05.030
P407
P577
2008-07-22T00:00:00Z