Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.
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How to Define the Latent Reservoir: Tools of the TradeTIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV InfectionImmune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?Reduction of HIV persistence following transplantation in HIV-infected kidney transplant recipientsPerforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level.A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.Th17 cells and regulatory T cells in elite control over HIV and SIV.Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers.HIV RNA levels in plasma and cervical-vaginal lavage fluid in elite controllers and HAART recipients.HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responsesEvidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individuals.The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid.HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses.An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription.HIV-1 continues to replicate and evolve in patients with natural control of HIV infectionHigh Rate of Non-detectable HIV-1 RNA Among Antiretroviral Drug Naive HIV Positive Individuals in NigeriaNatural suppression of human immunodeficiency virus type 1 replication is mediated by transitional memory CD8+ T cells.Finding a cure for HIV: will it ever be achievable?The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection.HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers.Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individualsA randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients.Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllersT cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite ControllersHIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles.Elevated caspase-3 expression and T-cell activation in elite suppressors.Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection.Immunologic and Virologic Progression in HIV Controllers: The Role of Viral "Blips" and Immune Activation in the ANRS CO21 CODEX Study.Investigation of Human Cancers for Retrovirus by Low-Stringency Target Enrichment and High-Throughput SequencingDetermination of HIV Status in African Adults With Discordant HIV Rapid Tests.Comprehensive analysis of unique cases with extraordinary control over HIV replication.
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Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Evidence for persistent low-le ...... nce of antiretroviral therapy.
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Hiroyu Hatano
Jeffrey M Linnen
Jeffrey N Martin
Joan Dunn-Williams
Joseph M McCune
Peter W Hunt
Philip J Norris
Rebecca Hoh
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P356
10.1128/JVI.01763-08
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P577
2008-10-22T00:00:00Z