Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state
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Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanismComplexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagminsDistinct initial SNARE configurations underlying the diversity of exocytosisA Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond ExocytosisComplexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activityAn extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.Re-examining how complexin inhibits neurotransmitter release.How could SNARE proteins open a fusion pore?Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivoComplexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanismsCommon intermediates and kinetics, but different energetics, in the assembly of SNARE proteins.Membrane curvature sensing by the C-terminal domain of complexin.Single reconstituted neuronal SNARE complexes zipper in three distinct stages.Mechanics of dynamin-mediated membrane fission.Positively charged amino acids at the SNAP-25 C terminus determine fusion rates, fusion pore properties, and energetics of tight SNARE complex zipperingRe-visiting the trans insertion model for complexin clamping.Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexinComplexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Snapshot of sequential SNARE assembling states between membranes shows that N-terminal transient assembly initializes fusionComplexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexFormation of Giant Unilamellar Proteo-Liposomes by Osmotic ShockKinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion.Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.A half-zippered SNARE complex represents a functional intermediate in membrane fusion.The impact of bacterial infection on mast cell degranulation.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.Adhesion energy can regulate vesicle fusion and stabilize partially fused states.Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.Mechanism of neurotransmitter release coming into focusComplexin arrests a neighborFocused clamping of a single neuronal SNARE complex by complexin under high mechanical tension
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Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 July 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Complexin activates and clamps ...... n intermediate energetic state
@en
Complexin activates and clamps ...... intermediate energetic state.
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type
label
Complexin activates and clamps ...... n intermediate energetic state
@en
Complexin activates and clamps ...... intermediate energetic state.
@nl
prefLabel
Complexin activates and clamps ...... n intermediate energetic state
@en
Complexin activates and clamps ...... intermediate energetic state.
@nl
P2093
P2860
P356
P1476
Complexin activates and clamps ...... n intermediate energetic state
@en
P2093
Claudio G Giraudo
Eric Perez
James E Rothman
P2860
P2888
P304
P356
10.1038/NSMB.2102
P577
2011-07-24T00:00:00Z