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Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolideThe LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activityPHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancerHSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cellsSomatic HIF2A gain-of-function mutations in paraganglioma with polycythemiaBetacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alphaB cell regulation of the anti-tumor response and role in carcinogenesisRedox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and TherapySequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspectiveHypoxic control of metastasisGlioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and RadioresistanceContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisAngiomodulatory properties of Rhodiola spp. and other natural antioxidantsCancer as a Proinflammatory Environment: Metastasis and CachexiaEpigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor HypoxiaHypoxia-mediated regulation of macrophage functions in pathophysiologyDefining normoxia, physoxia and hypoxia in tumours-implications for treatment responseHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionHypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): is it a rare exception?Thermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approachesThe Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation.Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic AdaptationHIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapyIn vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot studyHIF prolyl hydroxylase inhibitors for anemiaParadoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphomaTranslational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory DiseasesNanoformulation of D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for siRNA targeting HIF-1α for nasopharyngeal carcinoma therapyLoss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor modelCorrelation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients.Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell linesGD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.Expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and matrix metalloproteinase-2 in sacral chordomasDigoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.Adverse reactions to targeted and non-targeted chemotherapeutic drugs with emphasis on hypersensitivity responses and the invasive metastatic switch.The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The role of hypoxia-inducible factors in tumorigenesis.
@en
The role of hypoxia-inducible factors in tumorigenesis.
@nl
type
label
The role of hypoxia-inducible factors in tumorigenesis.
@en
The role of hypoxia-inducible factors in tumorigenesis.
@nl
prefLabel
The role of hypoxia-inducible factors in tumorigenesis.
@en
The role of hypoxia-inducible factors in tumorigenesis.
@nl
P2860
P356
P1476
The role of hypoxia-inducible factors in tumorigenesis
@en
P2093
A J Giaccia
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P2888
P304
P356
10.1038/CDD.2008.21
P577
2008-02-15T00:00:00Z