A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.
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Structural basis for molecular recognition of folic acid by folate receptorsBiology of the major facilitative folate transporters SLC19A1 and SLC46A1Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.Molecular and biochemical characterization of folate transport proteins in retinal Müller cellsOne-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.A novel PCFT gene mutation (p.Cys66LeufsX99) causing hereditary folate malabsorptionThe proton-coupled folate transporter: physiological and pharmacological roles.Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorptionMechanisms of membrane transport of folates into cells and across epithelia.Molecular characterization of folate receptor 1 mutations delineates cerebral folate transport deficiency.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma.Delineating the extracellular water-accessible surface of the proton-coupled folate transporter.Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.Reversible pancytopenia and immunodeficiency in a patient with hereditary folate malabsorption.CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) DeficiencyIntracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer.Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acidsDeterminants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors.Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.Contribution of tumoral and host solute carriers to clinical drug response.A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory diseaseFunctional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate tMutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption.Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expressionStructural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Uptake carriers and oncology drug safety.Hijacking solute carriers for proton-coupled drug transport.Recent advances in ligand targeted therapy.The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain.Application of the Key Events Dose-response Framework to Folate Metabolism.Role of Intramuscular Levofolinate Administration in the Treatment of Hereditary Folate Malabsorption: Report of Three Cases.
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A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 December 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A role for the proton-coupled ...... receptor-mediated endocytosis.
@en
A role for the proton-coupled folate transporter
@nl
type
label
A role for the proton-coupled ...... receptor-mediated endocytosis.
@en
A role for the proton-coupled folate transporter
@nl
prefLabel
A role for the proton-coupled ...... receptor-mediated endocytosis.
@en
A role for the proton-coupled folate transporter
@nl
P2093
P2860
P356
P1476
A role for the proton-coupled ...... receptor-mediated endocytosis.
@en
P2093
Estela Campanella
I David Goldman
Rongbao Zhao
Sang Hee Min
Yanhua Wang
P2860
P304
P356
10.1074/JBC.M807665200
P407
P577
2008-12-11T00:00:00Z