Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.
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Biology of the major facilitative folate transporters SLC19A1 and SLC46A1Philosophy of voltage-gated proton channelsSubstituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.The proton-coupled folate transporter: physiological and pharmacological roles.Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorptionMechanisms of membrane transport of folates into cells and across epithelia.Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphateThe human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorptionRandom mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of functionPharmGKB summary: methotrexate pathway.Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Contribution of tumoral and host solute carriers to clinical drug response.A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Experimentally optimized threading structures of the proton-coupled folate transporter.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
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Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@en
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@nl
type
label
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@en
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@nl
prefLabel
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@en
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@nl
P2093
P2860
P1476
Role of the glutamate 185 resi ...... ed folate transporter SLC46A1.
@en
P2093
Ersin Selcuk Unal
I David Goldman
Rongbao Zhao
P2860
P304
P356
10.1152/AJPCELL.00096.2009
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2009-04-29T00:00:00Z