CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. - Wikidata - wikimedia - TriplyDB

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.

http://www.wikidata.org/entity/Q37100737

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Hypoxia and Hypoxia-Inducible Factors in Leukemias Targeting the leukemia-stroma interaction in acute myeloid leukemia: rationale and latest evidence Advances in understanding the leukaemia microenvironment Role of Microenvironment in Resistance to Therapy in AML The Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent Cells Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104 Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia Treatment with a rho kinase inhibitor improves survival from graft-versus-host disease in mice after MHC-haploidentical hematopoietic cell transplantation.Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells.The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.Targeting hypoxia in the leukemia microenvironment The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo New strategies in acute myelogenous leukemia: leukemogenesis and personalized medicine.TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment Co-transplantation with mesenchymal stem cells expressing a SDF-1/HOXB4 fusion protein markedly improves hematopoietic stem cell engraftment and hematogenesis in irradiated mice.Contribution of bone microenvironment to leukemogenesis and leukemia progression.p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.What role for angiogenesis in childhood acute lymphoblastic leukaemia?Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment.Microenvironmental hypoxia regulates FLT3 expression and biology in AML.IL-8 as mediator in the microenvironment-leukaemia network in acute myeloid leukaemia.Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy.Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells.Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches.Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia: from bench to bedside.Apoptosis in leukemias: regulation and therapeutic targeting.Leukemia stem cells and microenvironment: biology and therapeutic targeting.Mobilization of hematopoietic stem and leukemia cells.Role of CXCR4 in the pathogenesis of acute myeloid leukemia.The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact.Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?Integration of hypoxic HIF-α signaling in blood cancers.Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia.Expression and regulation of AC133 and CD133 in glioblastoma.MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias.

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P2860

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.

http://www.wikidata.org/entity/Q37100737

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 28 October 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

CXCR4 expression and biologic ...... nt on oxygen partial pressure.

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CXCR4 expression and biologic ...... nt on oxygen partial pressure.

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type

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CXCR4 expression and biologic ...... nt on oxygen partial pressure.

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CXCR4 expression and biologic ...... nt on oxygen partial pressure.

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CXCR4 expression and biologic ...... nt on oxygen partial pressure.

@en

CXCR4 expression and biologic ...... nt on oxygen partial pressure.

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BLOOD-2008-06-161539

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P2093

Ismael Samudio

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Jared K Burks

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Karen Clise-Dwyer

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Michael Fiegl

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Zakar Mnjoyan

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P2860

Regulation of Fyn through translocation of activated Lck into lipid rafts

Exosomes: composition, biogenesis and function

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.

Analysis of lipid rafts in T cells.

CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion.

Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix.

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.

Regulation of the chemokine receptor CXCR4 by hypoxia.

Molecular mechanisms of soluble cytokine receptor generation.

Haematologic adaptation in patients with chronic bronchitis and pulmonary insufficiency.

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10.1182/BLOOD-2008-06-161539

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