Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. - Wikidata - wikimedia - TriplyDB

Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.

Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.

http://www.wikidata.org/entity/Q37111174

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Bisphosphonates for osteoarthritis Gap junctional regulation of signal transduction in bone cells Apoptotic osteocytes and the control of targeted bone resorption Connexin 43 hemichannels and intracellular signaling in bone cells American Society of Biomechanics Journal of Biomechanics Award 2013: cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures.Controlled delivery of zoledronate improved bone formation locally in vivo Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.The role of muscle loading on bone (Re)modeling at the developing enthesis.Role of TGF-β in a mouse model of high turnover renal osteodystrophy.Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone.Optimizing bone health and minimizing skeletal morbidity in men with prostate cancer Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability.A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice.Osteoblastic cell secretome: a novel role for progranulin during risedronate treatment Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice Connexin 43 channels are essential for normal bone structure and osteocyte viability Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice.Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures.Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling.Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone The role of bisphosphonates in multiple myeloma: mechanisms, side effects, and the future.Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.Elevated Intracellular Ca(2+) Signals by Oxidative Stress Activate Connexin 43 Hemichannels in Osteocytes.Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling Connexins and pannexins in the skeleton: gap junctions, hemichannels and more Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone Biological role of connexin intercellular channels and hemichannels Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.A new high-throughput screening-compatible gap junctional intercellular communication assay Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice.Gap junctions and hemichannels in signal transmission, function and development of bone Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.Beyond gap junctions: Connexin43 and bone cell signaling Biphosphonates-associated osteonecrosis of the jaw: the role of gene-environment interaction.Intrinsic mechanical behavior of femoral cortical bone in young, osteoporotic and bisphosphonate-treated individuals in low- and high energy fracture conditions Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates

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Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.

http://www.wikidata.org/entity/Q37111174

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2008 nî lūn-bûn

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name

Connexin 43 is required for th ...... cytes and osteoblasts in vivo.

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Connexin 43 is required for th ...... cytes and osteoblasts in vivo.

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type

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Connexin 43 is required for th ...... cytes and osteoblasts in vivo.

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Connexin 43 is required for th ...... cytes and osteoblasts in vivo.

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Connexin 43 is required for th ...... cytes and osteoblasts in vivo.

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Journal of Bone and Mineral Research

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Connexin 43 is required for th ...... cytes and osteoblasts in vivo.

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Jeff Thostenson

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Lilian I Plotkin

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Robert S Weinstein

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Stavros C Manolagas

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Virginia Lezcano

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P2860

Tissue- and site-specific DNA recombination in transgenic mice

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1

The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

Targeted oncogene activation by site-specific recombination in transgenic mice

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

Transduction of cell survival signals by connexin-43 hemichannels.

The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication.

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11

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23

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Teresita M. Bellido

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5255024

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18597631

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apoptotic process

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2648607

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