Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.
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Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting proteinC3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsActivated Ras interacts with the Ral guanine nucleotide dissociation stimulatorDifferential interactions of human Sos1 and Sos2 with Grb2The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayThe SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signallingN terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domainsRas-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of RafCharacterization of a guanine nucleotide dissociation stimulator for a ras-related GTPaseThe Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling propertiesShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsCloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for RasIdentification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3GBinding of NCK to SOS and activation of ras-dependent gene expressionIdentification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifBasis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factorsSos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptorsRas-GRF1 signaling is required for normal beta-cell development and glucose homeostasisThe N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calciumInsulin-stimulated disassociation of the SOS-Grb2 complexShc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytesPlatelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell typesRas oncogenes: split personalitiesApoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.Targeting Molecular Recognition: Exploring the Dual Role of Functional Pseudoprolines in the Design of SH3 Ligands This work was supported by the Swiss National Science Foundation.CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells.Regulation of the adapter molecule Grb2 by the Fc epsilon R1 in the mast cell line RBL2H3.An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membraneInteraction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin IThe GRB2/Sem-5 adaptor protein.Ras history: The saga continues.Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strainsIsolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton.Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development.Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.
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Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of murine homol ...... : potential activators of ras.
@en
Identification of murine homol ...... : potential activators of ras.
@nl
type
label
Identification of murine homol ...... : potential activators of ras.
@en
Identification of murine homol ...... : potential activators of ras.
@nl
prefLabel
Identification of murine homol ...... : potential activators of ras.
@en
Identification of murine homol ...... : potential activators of ras.
@nl
P2093
P2860
P356
P1476
Identification of murine homol ...... : potential activators of ras.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.14.6511
P407
P577
1992-07-01T00:00:00Z