USP9X enhances the polarity and self-renewal of embryonic stem cell-derived neural progenitors
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USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly.Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growthDeubiquitinating enzymes in cellular signaling and disease regulationLa FAM fatale: USP9X in development and diseaseNotch signaling maintains neural rosette polaritySeizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinaseLoss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesisUSP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesisAn atlas of altered expression of deubiquitinating enzymes in human cancerErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.Deubiquitylation of deubiquitylasesDEPTOR is a stemness factor that regulates pluripotency of embryonic stem cellsElevated expression of USP9X correlates with poor prognosis in human non-small cell lung cancer.Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibilityUbiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).A noncoding, regulatory mutation implicates HCFC1 in nonsyndromic intellectual disabilityRole of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.De Novo Loss-of-Function Mutations in USP9X Cause a Female-Specific Recognizable Syndrome with Developmental Delay and Congenital MalformationsUsp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus.Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel.Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism.Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitorsThe X-linked deubiquitinase USP9X is an integral component of centrosome.Regulation of pluripotency and differentiation by deubiquitinating enzymes.Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes.USP9X deletion elevates the density of oligodendrocytes within the postnatal dentate gyrus.The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth.USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output.
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USP9X enhances the polarity and self-renewal of embryonic stem cell-derived neural progenitors
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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USP9X enhances the polarity an ...... ell-derived neural progenitors
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USP9X enhances the polarity an ...... ll-derived neural progenitors.
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USP9X enhances the polarity an ...... ell-derived neural progenitors
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USP9X enhances the polarity an ...... ll-derived neural progenitors.
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USP9X enhances the polarity an ...... ell-derived neural progenitors
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USP9X enhances the polarity an ...... ll-derived neural progenitors.
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USP9X enhances the polarity an ...... ell-derived neural progenitors
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Lachlan A Jolly
Stephen A Wood
Verdon Taylor
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P304
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10.1091/MBC.E08-06-0596
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2009-01-28T00:00:00Z