Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members - Wikidata - wikimedia - TriplyDB

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

http://www.wikidata.org/entity/Q37148011

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The genetics and neuropathology of frontotemporal lobar degeneration Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders Expanding the Repertoire of Biomarkers for Alzheimer's Disease: Targeted and Non-targeted Approaches Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia Mechanisms of granulin deficiency: lessons from cellular and animal models Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment Progranulin: at the interface of neurodegenerative and metabolic diseases The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia.Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.Sporadic corticobasal syndrome due to FTLD-TDP.Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy Recent insights into the molecular genetics of dementia Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.Biomarkers in frontotemporal lobar degenerations--progress and challenges.Progranulin protein levels are differently regulated in plasma and CSF.Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.Clinical phenotypes and genetic biomarkers of FTLD.Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population rs5848 polymorphism and serum progranulin level Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.Brain progranulin expression in GRN-associated frontotemporal lobar degeneration A network of RNA and protein interactions in Fronto Temporal Dementia.Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.Low plasma progranulin levels in children with autism.TMEM106B a novel risk factor for frontotemporal lobar degeneration Interactions between traumatic brain injury and frontotemporal degeneration.Progranulin: a growth factor, a novel TNFR ligand and a drug target Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration.Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.

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Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

http://www.wikidata.org/entity/Q37148011

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article scientifique

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bilimsel makale

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scientific article published on 21 January 2009

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vedecký článok

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Plasma progranulin levels pred ...... nd asymptomatic family members

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Plasma progranulin levels pred ...... nd asymptomatic family members

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Plasma progranulin levels pred ...... nd asymptomatic family members

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Anne Rovelet-Lecrux

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Bradley Boeve

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Gina Bisceglio

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Julia Crook

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Karen Kuntz

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Katie Swanson

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Matt Baker

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Neill R Graff-Radford

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NiCole Finch

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Rebecca Surtees

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P2860

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

The logopenic/phonological variant of primary progressive aphasia.

Primary progressive aphasia--a language-based dementia.

HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin

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583-591

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scholarly article

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10.1093/BRAIN/AWN352

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P433

Pt 3

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132

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Rosa Rademakers

Dennis W. Dickson

Vincent Deramecourt

Ronald C. Petersen

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2009-01-21T00:00:00Z

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23806779

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19158106

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2664450

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