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Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics

Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics

http://www.wikidata.org/entity/Q37156962

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Studying Cellular Signal Transduction with OMIC Technologies Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2 Distinct genetic alterations in colorectal cancer.The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.Dynamics of TGF-β/Smad signaling Plasticity of TGF-β signaling Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting.Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling.Vicious cycle of TGF-β signaling in tumor progression and metastasis.Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy.Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics.Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-β and induce Tregs development via TGF-β.Engineering fibrin-binding TGF-β1 for sustained signaling and contractile function of MSC based vascular constructs Strategies to reduce dendritic cell activation through functional biomaterial design Student award for outstanding research winner in the Ph.D. category for the 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012: synthesis and application of photodegradable microspheres for spatiotemporal control of protein delivery.Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching.Immobilized epidermal growth factor stimulates persistent, directed keratinocyte migration via activation of PLCγ1 Differential and synergistic effects of mechanical stimulation and growth factor presentation on vascular wall function.Sustained delivery of bioactive TGF-β1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells.M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop.Mysteries of TGF-β Paradox in Benign and Malignant Cells.Measuring TGF-β Ligand Dynamics in Culture Medium.PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition.Covalently tethered TGF-β1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production.Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway.Trafficking coordinate description of intracellular transport control of signaling networks.Covalently tethered transforming growth factor beta in PEG hydrogels promotes chondrogenic differentiation of encapsulated human mesenchymal stem cells.Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.Induction of senescence in primary glioblastoma cells by serum and TGFβ.Thiol-ene photopolymerizations provide a facile method to encapsulate proteins and maintain their bioactivity.Affinity peptides protect transforming growth factor beta during encapsulation in poly(ethylene glycol) hydrogels.Spatiotemporal Control of TGF-β Signaling with Light.Quantitative single-molecule study of TGF-β/Smad signaling.Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.TGF-β and IL-6 family signalling crosstalk: an integrated model.

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P2860

Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics

http://www.wikidata.org/entity/Q37156962

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 February 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Transforming growth factor bet ...... ant of Smad signaling kinetics

@en

Transforming growth factor bet ...... nt of Smad signaling kinetics.

@nl

type

label

Transforming growth factor bet ...... ant of Smad signaling kinetics

@en

Transforming growth factor bet ...... nt of Smad signaling kinetics.

@nl

prefLabel

Transforming growth factor bet ...... ant of Smad signaling kinetics

@en

Transforming growth factor bet ...... nt of Smad signaling kinetics.

@nl

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Molecular and Cellular Biology

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Transforming growth factor bet ...... ant of Smad signaling kinetics

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David C Clarke

http://www.w3.org/2001/XMLSchema#string

Meredith L Brown

http://www.w3.org/2001/XMLSchema#string

Richard A Erickson

http://www.w3.org/2001/XMLSchema#string

Yigong Shi

http://www.w3.org/2001/XMLSchema#string

P2860

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Early endosomal regulation of Smad-dependent signaling in endothelial cells

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Signal processing in the TGF-beta superfamily ligand-receptor network

Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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2443-2455

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scholarly article

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10.1128/MCB.01443-08

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9

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29

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19223462

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