Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
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Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming abilityCBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesisThe PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesisGSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesisThe miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expressionThe niche under siege: novel targets for metastasis therapyRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaHuman keratinocytes have two interconvertible modes of proliferation.Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaLSD1 inhibition: a therapeutic strategy in cancer?A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesisA Myc network accounts for similarities between embryonic stem and cancer cell transcription programsNOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive nichesRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaGene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemiaPluripotent transcription factors possess distinct roles in normal versus transformed human stem cells.Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.7-difluoromethoxyl-5,4'-di-n-octyl genistein inhibits ovarian cancer stem cell characteristics through the downregulation of FOXM1.miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemiaThe Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia.Cancer stem cells: a stride towards cancer cure?Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformationBlockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cellsMLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states.Transcription factor Oct1 is a somatic and cancer stem cell determinant.NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemiaHMGB1 in health and disease.MicroRNA programs in normal and aberrant stem and progenitor cells.KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemiaA flexible reporter system for direct observation and isolation of cancer stem cellsIntegrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by MybMLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Hierarchical maintenance of ML ...... c rather than adult stem cells
@en
Hierarchical maintenance of ML ...... rather than adult stem cells.
@nl
type
label
Hierarchical maintenance of ML ...... c rather than adult stem cells
@en
Hierarchical maintenance of ML ...... rather than adult stem cells.
@nl
prefLabel
Hierarchical maintenance of ML ...... c rather than adult stem cells
@en
Hierarchical maintenance of ML ...... rather than adult stem cells.
@nl
P2093
P2860
P1433
P1476
Hierarchical maintenance of ML ...... c rather than adult stem cells
@en
P2093
Christina J Matheny
Gary J Spencer
Howard Y Chang
James R Downing
Masayuki Iwasaki
Michael L Cleary
Sheila A Shurtleff
Tim C P Somervaille
P2860
P304
P356
10.1016/J.STEM.2008.11.015
P407
P577
2009-02-01T00:00:00Z