A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
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RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory functionApolipoprotein C3 gene variants in nonalcoholic fatty liver diseaseAssociation between a literature-based genetic risk score and cardiovascular events in womenIn search of low-frequency and rare variants affecting complex traitsMetabolism of very-low-density lipoprotein and low-density lipoprotein containing apolipoprotein C-III and not other small apolipoproteinsTriglyceride-Rich Lipoproteins and Remnants: Targets for Therapy?Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to GreenlandHuman Knockout Carriers: Dead, Diseased, Healthy, or Improved?Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and SteatohepatitisCardiovascular pharmacogenomics: current status and future directionsTop-down proteomics in health and disease: challenges and opportunitiesIslet inflammation in plain sightExome sequencing and complex disease: practical aspects of rare variant association studiesThe emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolismMass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular diseaseWhy Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?Missense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: evidence that ApoC-III plays a major role in the formation of lExpression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditionsFunctional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemiaGenetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination SurveyModulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expressionCommon variants associated with plasma triglycerides and risk for coronary artery diseaseGenetic determinants of myocardial dysfunction.Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Loss-of-function mutations in APOC3, triglycerides, and coronary diseaseAn Apo-14 promoter-driven transgenic zebrafish that marks liver organogenesis.Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County.The impact of rare and low-frequency genetic variants in common diseaseAmyloid triangles, squares, and loops of apolipoprotein C-III.Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traitsImplementation of pharmacogenetics: the University of Maryland Personalized Anti-platelet Pharmacogenetics Program.Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.Quantitative analysis of intact apolipoproteins in human HDL by top-down differential mass spectrometry.The genetics of obesity and the metabolic syndrome.Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices.Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) studyDistribution and medical impact of loss-of-function variants in the Finnish founder population.Antiretroviral treatment-induced dyslipidemia in HIV-infected patients is influenced by the APOC3-related rs10892151 polymorphism.Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man.
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A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A null mutation in human APOC3 ...... and apparent cardioprotection.
@en
A null mutation in human APOC3 ...... and apparent cardioprotection.
@nl
type
label
A null mutation in human APOC3 ...... and apparent cardioprotection.
@en
A null mutation in human APOC3 ...... and apparent cardioprotection.
@nl
prefLabel
A null mutation in human APOC3 ...... and apparent cardioprotection.
@en
A null mutation in human APOC3 ...... and apparent cardioprotection.
@nl
P2093
P2860
P356
P1433
P1476
A null mutation in human APOC3 ...... and apparent cardioprotection.
@en
P2093
Coleen M Damcott
Haiqing Shen
Jeffrey R O'Connell
John C McLenithan
John Shelton
Lawrence F Bielak
Michael Miller
Patricia A Peyser
Richard B Horenstein
Sandra H Ott
P2860
P304
P356
10.1126/SCIENCE.1161524
P407
P577
2008-12-01T00:00:00Z