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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repairTelomeres in aging and disease: lessons from zebrafishAlternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progressionComplex network analysis of CA3 transcriptome reveals pathogenic and compensatory pathways in refractory temporal lobe epilepsySLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with TelomeresComplex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.Length-dependent processing of telomeres in the absence of telomerase.The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeTelomere elongation chooses TERRA ALTernativesThe protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers.Telomerase enzymatic component hTERT shortens long telomeres in human cells.Break-induced DNA replicationMultiple Mechanisms Contribute To Telomere Maintenance.Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scramblingDepletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells.SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediatesCaenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengthsDifferent expression of alternative lengthening of telomere (ALT)-associated proteins/mRNAs in osteosarcoma cell lines.Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Arsenic exposure through drinking water is associated with longer telomeres in peripheral bloodAcute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway.The telomere-associated homeobox-containing protein TAH1/HMBOX1 participates in telomere maintenance in ALT cellsSMARCAL1 Resolves Replication Stress at ALT Telomeres.Telomeric armor: the layers of end protection.Localization-dependent and -independent roles of SLX4 in regulating telomeres.Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.Structural identity of telomeric complexes.Telomerase-independent paths to immortality in predictable cancer subtypes.PML body meets telomere: the beginning of an ALTernate ending?Regulation of recombination and genomic maintenance.Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.Telomere recombination pathways: tales of several unhappy marriages.MUS81-EME2 promotes replication fork restart.Precarious maintenance of simple DNA repeats in eukaryotes.A three-dimensional colocalization RNA interference screening platform to elucidate the alternative lengthening of telomeres pathway.The Telomeric Response to Viral Infection.
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description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Telomere recombination requires the MUS81 endonuclease.
@en
Telomere recombination requires the MUS81 endonuclease.
@nl
type
label
Telomere recombination requires the MUS81 endonuclease.
@en
Telomere recombination requires the MUS81 endonuclease.
@nl
prefLabel
Telomere recombination requires the MUS81 endonuclease.
@en
Telomere recombination requires the MUS81 endonuclease.
@nl
P2093
P2860
P356
P1433
P1476
Telomere recombination requires the MUS81 endonuclease
@en
P2093
Curtis C Harris
Ignacio Gonzalez-Suarez
Sicong Zeng
Tej K Pandita
P2860
P2888
P304
P356
10.1038/NCB1867
P577
2009-04-12T00:00:00Z