Design of small-molecule peptidic and nonpeptidic Smac mimetics. - Wikidata - wikimedia - TriplyDB

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

http://www.wikidata.org/entity/Q37176751

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Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics Targeting the apoptosis pathway in hematologic malignancies Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3 The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro Potential therapeutic benefits of strategies directed to mitochondria.Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.An index for characterization of natural and non-natural amino acids for peptidomimetics Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.Lipid-conjugated Smac analogues.The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac.Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer.The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer.Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer.Anti-apoptotic genes in the survival of monocytic cells during infection Livin/BIRC7 expression as malignancy marker in adrenocortical tumors.Targeting inhibitor of apoptosis proteins for therapeutic intervention.Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities.Small Molecules for Active Targeting in Cancer.Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP).Double-clicking peptides onto phosphorothioate oligonucleotides: combining two proapoptotic agents in one molecule.IAPs and Cell Death.Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide.Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist.Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

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P2860

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

http://www.wikidata.org/entity/Q37176751

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on October 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@en

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@nl

type

label

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@en

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@nl

prefLabel

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@en

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@nl

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Accounts of Chemical Research

P1476

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

@en

P2093

Chao-Yie Yang

http://www.w3.org/2001/XMLSchema#string

Dongguang Qian

http://www.w3.org/2001/XMLSchema#string

Haiying Sun

http://www.w3.org/2001/XMLSchema#string

Jianfeng Lu

http://www.w3.org/2001/XMLSchema#string

Longchuan Bai

http://www.w3.org/2001/XMLSchema#string

Qian Cai

http://www.w3.org/2001/XMLSchema#string

Shaomeng Wang

http://www.w3.org/2001/XMLSchema#string

Su Qiu

http://www.w3.org/2001/XMLSchema#string

Yuefeng Peng

http://www.w3.org/2001/XMLSchema#string

Zaneta Nikolovska-Coleska

http://www.w3.org/2001/XMLSchema#string

P2860

Structural basis of caspase-7 inhibition by XIAP

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Structural basis for the inhibition of caspase-3 by XIAP

Mechanism of XIAP-mediated inhibition of caspase-9

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

TNF-alpha induces two distinct caspase-8 activation pathways

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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1264-1277

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scholarly article

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10.1021/AR8000553

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10

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41

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2008-10-01T00:00:00Z

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23400133

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18937395

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2676167

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