GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site.
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A predicted binding site for cholesterol on the GABAA receptorMapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsGamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activityCurcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling.Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populationsMultiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sitesModeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4.Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines.Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.Clinical and molecular pharmacology of etomidate.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Engineering a prokaryotic Cys-loop receptor with a third functional domain.Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channelMutations in the GABAA receptor that mimic the allosteric ligand etomidate.Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domainState-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptorsInter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptorsAssessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.General anesthetic actions on GABA(A) receptors.GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.The discovery of new anesthetics by targeting GABA(A) receptors.A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.Metal bridges to probe membrane ion channel structure and function.Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.The sticky issue of neurosteroids and GABA(A) receptors.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.
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GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@en
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@nl
type
label
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@en
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@nl
prefLabel
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@en
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@nl
P2093
P2860
P1476
GABA-induced intersubunit conf ...... enous anesthetic binding site.
@en
P2093
Michaela Jansen
Myles H Akabas
P2860
P304
P356
10.1523/JNEUROSCI.6090-08.2009
P407
P577
2009-03-01T00:00:00Z