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Structural insights into TDP-43 in nucleic-acid binding and domain interactionsPhosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.TDP-43 is a developmentally regulated protein essential for early embryonic development.Sporadic corticobasal syndrome due to FTLD-TDP.Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chainsMolecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSNeuronal function and dysfunction of Drosophila dTDPTAR DNA-binding protein 43 in neurodegenerative disease.Drosophila melanogaster in the study of human neurodegeneration.The emerging use of in vivo optical imaging in the study of neurodegenerative diseases.Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injuryTDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions.TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.The complexities of p97 function in health and diseaseValproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.Frontal cortex neuropathology in dementia pugilistica.Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity.Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypesEnrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosisThe p.A382T TARDBP gene mutation in Sardinian patients affected by Parkinson's disease and other degenerative parkinsonismsExpression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 ProteinopathiesTDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander.Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disordersTDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.Biomarkers in amyotrophic lateral sclerosis: facts and future horizons.Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivoRNA-binding proteins with prion-like domains in ALS and FTLD-U.Interaction between pathogenic proteins in neurodegenerative disorders.TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update.The puzzling case of hyperexcitability in amyotrophic lateral sclerosis.Emerging roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice.Familial semantic dementia with P301L mutation in the Tau gene.Prevalence of brain and spinal cord inclusions, including dipeptide repeat proteins, in patients with the C9ORF72 hexanucleotide repeat expansion: a systematic neuropathological review.Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 October 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
TDP-43: a novel neurodegenerative proteinopathy.
@en
TDP-43: a novel neurodegenerative proteinopathy.
@nl
type
label
TDP-43: a novel neurodegenerative proteinopathy.
@en
TDP-43: a novel neurodegenerative proteinopathy.
@nl
prefLabel
TDP-43: a novel neurodegenerative proteinopathy.
@en
TDP-43: a novel neurodegenerative proteinopathy.
@nl
P2860
P1476
TDP-43: a novel neurodegenerative proteinopathy.
@en
P2093
Mark S Forman
Virginia M-Y Lee
P2860
P304
P356
10.1016/J.CONB.2007.08.005
P577
2007-10-23T00:00:00Z