Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsAmyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryThe past and the future of Alzheimer's disease CSF biomarkers-a journey toward validated biochemical tests covering the whole spectrum of molecular eventsTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseasePathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseNeuropathological alterations in Alzheimer diseaseA window into the heterogeneity of human cerebrospinal fluid Aβ peptidesCerebrospinal fluid and blood biomarkers in Alzheimer's diseaseSpines, plasticity, and cognition in Alzheimer's model miceFLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylationAβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's diseaseIntracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 miceNeprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosisAmyloid beta from axons and dendrites reduces local spine number and plasticity.Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.Brain amyloid-β oligomers in ageing and Alzheimer's disease.Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND).Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chainsComputational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityDistinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease.Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method.Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouseAPP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesisThe presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.Tissue transglutaminase-mediated glutamine deamidation of beta-amyloid peptide increases peptide solubility, whereas enzymatic cross-linking and peptide fragmentation may serve as molecular triggers for rapid peptide aggregationTargeting Abeta and tau in Alzheimer's disease, an early interim reportAnti-amyloidogenic activity of IgGs contained in normal plasmaAmyloid-beta immunotherapy for Alzheimer's diseaseAssociation of the RAGE G82S polymorphism with Alzheimer's disease.Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization.Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.Cognition, glucose metabolism and amyloid burden in Alzheimer's disease.Selective induction of calcineurin activity and signaling by oligomeric amyloid betaAbeta(1-42) enhances neuronal excitability in the CA1 via NR2B subunit-containing NMDA receptorsMemantine prevents memory consolidation failure induced by soluble beta amyloid in rats.Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.
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P2860
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Amyloid beta protein dimer-con ...... systemic passive immunization
@en
Amyloid beta protein dimer-con ...... systemic passive immunization.
@nl
type
label
Amyloid beta protein dimer-con ...... systemic passive immunization
@en
Amyloid beta protein dimer-con ...... systemic passive immunization.
@nl
prefLabel
Amyloid beta protein dimer-con ...... systemic passive immunization
@en
Amyloid beta protein dimer-con ...... systemic passive immunization.
@nl
P2093
P2860
P50
P1476
Amyloid beta protein dimer-con ...... systemic passive immunization
@en
P2093
Alfred T Welzel
Anders Wallin
Cynthia A Lemere
Dennis J Selkoe
Dominic M Walsh
Igor Klyubin
Roger Anwyl
Vicki Betts
William K Cullen
P2860
P304
P356
10.1523/JNEUROSCI.5161-07.2008
P407
P577
2008-04-01T00:00:00Z