Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι
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Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic strokeAtypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus.PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunctionSynthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitorsHepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytesHepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes MellitusBMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humansMetabolic master regulators: sharing information among multiple systems.Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance.Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance.Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzhei
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P2860
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 05 January 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι
@en
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι.
@nl
type
label
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι
@en
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι.
@nl
prefLabel
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι
@en
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι.
@nl
P2093
P2860
P921
P1433
P1476
Correction of metabolic abnorm ...... of hepatic protein kinase C-ι
@en
P2093
Alan P Fields
Michael Leitges
Mildred Acevedo-Duncan
Mini P Sajan
Robert V Farese
Sonali Nimal
Stephen Mastorides
Ursula Braun
P2860
P304
P356
10.1016/J.METABOL.2011.12.008
P577
2012-01-05T00:00:00Z