Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. - Wikidata - wikimedia - TriplyDB

Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.

Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.

http://www.wikidata.org/entity/Q37218234

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Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation Matriptase autoactivation is tightly regulated by the cellular chemical environments Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors.Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer Type II transmembrane serine proteases as potential targets for cancer therapy.Mechanisms of hepatocyte growth factor activation in cancer tissues.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein.Activated matriptase as a target to treat breast cancer with a drug conjugate.

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Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.

http://www.wikidata.org/entity/Q37218234

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

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Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

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type

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Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

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Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

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Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

@en

Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

@nl

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J.AJPATH.2013.06.024

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The American Journal of Pathology

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Imbalanced matriptase pericell ...... of malignant B-cell lymphomas.

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Annie H Zuo

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Chen-Yong Lin

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Feng-Pai Chou

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Hiroaki Kataoka

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Jehng-Kang Wang

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Ken H Young

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Michael Johnson

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Robert J Barndt

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Ronald B Gartenhaus

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Xianfeng F Zhao

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P2860

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk

Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues

Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor

A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover

Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor.

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