Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1 - Wikidata - wikimedia - TriplyDB

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

http://www.wikidata.org/entity/Q28180175

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Pro-urokinase-type plasminogen activator is a substrate for hepsin A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator Structural insight into distinct mechanisms of protease inhibition by antibodies Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1 The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.Local protease signaling contributes to neural tube closure in the mouse embryo Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.An allosteric anti-hepsin antibody derived from a constrained phage display library.Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex.Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.Matriptase: potent proteolysis on the cell surface.Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells Prostasin: An Epithelial Sodium Channel Regulator.Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.Membrane-anchored serine proteases in health and disease.Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.Targeting the Met signaling pathway in renal cancer.Matriptase expression and zymogen activation in human pilosebaceous unit.Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).Structural and mechanistic insight into how antibodies inhibit serine proteases.TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases.Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain.HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.

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P2860

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

http://www.wikidata.org/entity/Q28180175

description

2003 nî lūn-bûn

@nan

2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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Tissue expression, protease sp ...... a new splice variant of HAI-1

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P1433

Journal of Biological Chemistry

P1476

Tissue expression, protease sp ...... a new splice variant of HAI-1

@en

P2093

Charles Eigenbrot

http://www.w3.org/2001/XMLSchema#string

Daniel Kirchhofer

http://www.w3.org/2001/XMLSchema#string

J Michael Elliott

http://www.w3.org/2001/XMLSchema#string

Jennifer Stamos

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Mark Peek

http://www.w3.org/2001/XMLSchema#string

Paul Moran

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Racquel T Corpuz

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Robert A Lazarus

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Saloumeh Kadkhodayan

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Wei Li

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P2860

Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors

Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains

Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer

Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor

Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo

Peptide exosite inhibitors of factor VIIa as anticoagulants

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36341-9

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scholarly article

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10.1074/JBC.M304643200

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P433

38

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P478

278

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2003-09-19T00:00:00Z

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12815039

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