Allostery: an illustrated definition for the 'second secret of life'.
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A structure filter for the Eukaryotic Linear Motif Resource.The ensemble nature of allosteryDrugs for allosteric sites on receptorsMichaelis-Menten at 100 and allosterism at 50: driving molecular motors in a hailstorm with noisy ATPase engines and allosteric transmissionAllosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock ModelThe pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allosteryAllosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) FamilyNovel Allosteric Modulators of G Protein-coupled ReceptorsA unified view of "how allostery works"Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiersSequence analysis and molecular characterization of Clonorchis sinensis hexokinase, an unusual trimeric 50-kDa glucose-6-phosphate-sensitive allosteric enzymeAdvanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasisCapturing cooperative interactions with the PSI-MI formatDistinguishing the Interactions in the Fructose 1,6-Bisphosphate Binding Site of Human Liver Pyruvate Kinase That Contribute to AllosteryMutations in Antibody Fragments Modulate Allosteric Response Via Hydrogen-Bond Network Fluctuations.Modeling allosteric signal propagation using protein structure networksUsing mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors.Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Discovery of a novel inhibitor of kinesin-like protein KIFC1Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Identification of allosteric-activating drug leads for human liver pyruvate kinase2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Allosteric response is both conserved and variable across three CheY orthologs.Metalloregulatory proteins: metal selectivity and allosteric switching.Hill coefficients, dose-response curves and allosteric mechanisms.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryComputational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled ReceptorsInhibitors of the AAA+ chaperone p97Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface.AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems.ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks.Study on the Application of the Combination of TMD Simulation and Umbrella Sampling in PMF Calculation for Molecular Conformational Transitions.What Mutagenesis Can and Cannot Reveal About Allostery.Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsLong term myriocin treatment increases MRP1 transport activity.Conformational ensemble modulates cooperativity in the rate-determining catalytic step in the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex.Influence of Secondary-Structure Folding on the Mutually Exclusive Folding Process of GL5/I27 Protein: Evidence from Molecular Dynamics Simulations.An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates.On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.G protein coupled receptors as allosteric proteins and the role of allosteric modulators.
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P2860
Allostery: an illustrated definition for the 'second secret of life'.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Allostery: an illustrated definition for the 'second secret of life'.
@en
Allostery: an illustrated definition for the 'second secret of life'.
@nl
type
label
Allostery: an illustrated definition for the 'second secret of life'.
@en
Allostery: an illustrated definition for the 'second secret of life'.
@nl
prefLabel
Allostery: an illustrated definition for the 'second secret of life'.
@en
Allostery: an illustrated definition for the 'second secret of life'.
@nl
P2860
P1476
Allostery: an illustrated definition for the 'second secret of life'.
@en
P2093
Aron W Fenton
P2860
P304
P356
10.1016/J.TIBS.2008.05.009
P577
2008-08-15T00:00:00Z