Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase
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A network of multi-tasking proteins at the DNA replication fork preserves genome stabilityEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesionThe S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae.The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiaeMurine Pif1 interacts with telomerase and is dispensable for telomere function in vivoSaccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activitiesControl of Rad52 recombination activity by double-strand break-induced SUMO modification.Effects of mutations in SGS1 and in genes functionally related to SGS1 on inverted repeat-stimulated spontaneous unequal sister-chromatid exchange in yeastSgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.Srs2: the "Odd-Job Man" in DNA repair.Unwinding the functions of the Pif1 family helicases.Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress.Telomeres: structures in need of unwinding.The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.The amino terminus of the Saccharomyces cerevisiae DNA helicase Rrm3p modulates protein function altering replication and checkpoint activityTopo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents.Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae.The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae.Suppression of spontaneous genome rearrangements in yeast DNA helicase mutantsBudding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA ReplicationA Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.Temporal separation of replication and recombination requires the intra-S checkpoint.A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityRoles of Pif1-like helicases in the maintenance of genomic stability.RecQ helicases: lessons from model organisms.Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3pRrm3 protects the Saccharomyces cerevisiae genome from instability at nascent sites of retrotranspositionRecruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival.A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instabilityA pattern recognition approach to infer time-lagged genetic interactions.Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein.The Balance between Recombination Enzymes and Accessory Replicative Helicases in Facilitating Genome Duplication.Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Impairment of replication fork progression mediates RNA polII transcription-associated recombination.Defects in DNA lesion bypass lead to spontaneous chromosomal rearrangements and increased cell death.
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Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase
@en
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase.
@nl
type
label
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase
@en
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase.
@nl
prefLabel
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase
@en
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase.
@nl
P2860
P1476
Requirement of Rrm3 helicase f ...... lacking Srs2 or Sgs1 helicase
@en
P2093
Kristina H Schmidt
Richard D Kolodner
P2860
P304
P356
10.1128/MCB.24.8.3213-3226.2004
P407
P577
2004-04-01T00:00:00Z