Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology - Wikidata - wikimedia - TriplyDB

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

http://www.wikidata.org/entity/Q37296372

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Protein phosphatase 2A dysfunction in Alzheimer's disease Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET Protein phosphatases and Alzheimer's disease Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton Signaling mechanisms and disrupted cytoskeleton in the diphenyl ditelluride neurotoxicity Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling mTOR-dependent signalling in Alzheimer's disease Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.Unveiling clusters of RNA transcript pairs associated with markers of Alzheimer's disease progression.Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia.Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease.Sustained postexercise increases in AS160 Thr642 and Ser588 phosphorylation in skeletal muscle without sustained increases in kinase phosphorylation Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model Early glycogen synthase kinase-3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.The role of tau in Alzheimer's disease and related disorders.Screening of treatment targets for Alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation.Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis.Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease.Environmental factors in the development and progression of late-onset Alzheimer's disease.The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.Zinc binds to and directly inhibits protein phosphatase 2A in vitro Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders.Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line.Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.Tau kinases and phosphatases.Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats.Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation.Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

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Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

http://www.wikidata.org/entity/Q37296372

description

article científic

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article scientifique

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articolo scientifico

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bilimsel makale

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scientific article published on 19 January 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

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Phosphorylated PP2A

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type

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Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

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Phosphorylated PP2A

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prefLabel

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

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Phosphorylated PP2A

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J.1582-4934.2008.00249.X

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Journal of Cellular and Molecular Medicine

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Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

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C Bjorkdahl

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H Tanila

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J-A Gustafsson

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J-J Pei

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J-Z Wang

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X-W Zhou

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Y Cao

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Z-Z Guan

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P2860

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain.

Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

Flicking the switches: phosphorylation of serine/threonine protein phosphatases.

Protein phosphatase 2A: a panoply of enzymes.

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus.

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241-257

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10.1111/J.1582-4934.2008.00249.X

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1

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12

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2008-01-19T00:00:00Z

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5642273

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18208556

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Alzheimer's disease

phosphorylation

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3823485

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