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Competitive repair pathways in immunoglobulin gene hypermutation.

Competitive repair pathways in immunoglobulin gene hypermutation.

http://www.wikidata.org/entity/Q37326085

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Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites AID and Apobec3G haphazard deamination and mutational diversity Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation Does DNA repair occur during somatic hypermutation?Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells.Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Translesion synthesis polymerases in the prevention and promotion of carcinogenesis.A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.

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Competitive repair pathways in immunoglobulin gene hypermutation.

http://www.wikidata.org/entity/Q37326085

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on March 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Competitive repair pathways in immunoglobulin gene hypermutation.

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Competitive repair pathways in immunoglobulin gene hypermutation.

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type

label

Competitive repair pathways in immunoglobulin gene hypermutation.

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Competitive repair pathways in immunoglobulin gene hypermutation.

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prefLabel

Competitive repair pathways in immunoglobulin gene hypermutation.

@en

Competitive repair pathways in immunoglobulin gene hypermutation.

@nl

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Philosophical Transactions of the Royal Society B

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Competitive repair pathways in immunoglobulin gene hypermutation

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Ahmad Faili

http://www.w3.org/2001/XMLSchema#string

Claude-Agnès Reynaud

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Frédéric Delbos

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Jean-Claude Weill

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Quentin Guéranger

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P2860

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.

Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

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613-619

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scholarly article

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10.1098/RSTB.2008.0206

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1517

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364

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2009-03-01T00:00:00Z

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23475103

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19010770

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2660922

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