Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.
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Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loopsDNA triplet repeat expansion and mismatch repairNew insights into the mechanism of DNA mismatch repairPms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissuesMutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesisIncision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extractsIsolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Eukaryotic Mismatch Repair in Relation to DNA ReplicationPurification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβConformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.Repeat instability during DNA repair: Insights from model systemsInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisThe Repeat Expansion Diseases: The dark side of DNA repair.In vitro repair of DNA hairpins containing various numbers of CAG/CTG trinucleotide repeats.Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions.MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells.Oligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability.Trinucleotide repeat expansions catalyzed by human cell-free extractsCrosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair.The dual nature of mismatch repair as antimutator and mutator: for better or for worse.Replication stalling and DNA microsatellite instability.Break-induced replication links microsatellite expansion to complex genome rearrangements.
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Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 June 2009
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Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.
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Mismatch recognition protein MutSbeta does not hijack
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label
Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.
@en
Mismatch recognition protein MutSbeta does not hijack
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prefLabel
Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.
@en
Mismatch recognition protein MutSbeta does not hijack
@nl
P2093
P2860
P356
P1476
Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro
@en
P2093
P2860
P304
20452-20456
P356
10.1074/JBC.C109.014977
P407
P577
2009-06-12T00:00:00Z