Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

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http://www.wikidata.org/entity/Q37345034

Q37345034

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Epigenetic regulation of fetal globin gene expression in adult erythroid cells Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice Future prospects for treatment of hemoglobinopathies.Control of globin gene expression during development and erythroid differentiation Demethylating Agents in the Treatment of Cancer Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues 5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis.Stage-specific DNA methylation in a fungal plant pathogen MBD2 contributes to developmental silencing of the human ε-globin gene.Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms.Pharmacotherapy in sickle cell disease--state of the art and future prospects Fetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia.Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors.Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea.Procainamide is a specific inhibitor of DNA methyltransferase 1.Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate Carcinogenicity and haemoglobin synthesis induction by cytidine analogues.The genomics of new drugs in sickle cell disease.Pharmacologic manipulation of fetal hemoglobin in the hemoglobinopathies.Pharmacologic manipulation of fetal hemoglobin. Update on clinical trials with hydroxyurea.Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection.Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression.Developmental characterization and chromosomal mapping of the 5-azacytidine-sensitive fluF locus of Aspergillus nidulans.Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.Changes in structure and methylation pattern in a cluster of thymidine kinase genes.Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation.Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease Epigenetics of beta-globin gene regulation G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene.DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues Novel approaches to the treatment of sickle cell disease: the potential of histone deacetylase inhibitors.The rationale and use of hypomethylation agents in adult acute myeloid leukemia.Chemotherapy and hemoglobin F synthesis in sickle cell disease.Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup.A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.Differentiation of leukemia cells by chemotherapeutic agents.Induction of fetal hemoglobin and ABCB1 gene expression in 9-β-D-arabinofuranosylguanine-resistant MOLT-4 cells.

P2860

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P2860

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

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http://www.wikidata.org/entity/Q37345034

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on August 1983

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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