SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans
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DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysSMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayRibosome-based quality control of mRNA and nascent peptidesMechanism and regulation of the nonsense-mediated decay pathwaySMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planariansStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryInhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIIITemporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxAA novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansSmg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.A role for nonsense-mediated mRNA decay in plants: pathogen responses are induced in Arabidopsis thaliana NMD mutants.Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decayATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegansDhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegansA highly conserved region essential for NMD in the Upf2 N-terminal domainNMD: At the crossroads between translation termination and ribosome recycling.Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegansN- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMDMechanistic insights and identification of two novel factors in the C. elegans NMD pathway.Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons.Navigating without a road mapGenetic suppressors of Caenorhabditis elegans pha-4/FoxA identify the predicted AAA helicase ruvb-1/RuvB.Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6Heat shock activates splicing at latent alternative 5' splice sites in nematodes.SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria.NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events.A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type.mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesisThe multiple lives of NMD factors: balancing roles in gene and genome regulationA gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment.
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SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on September 2004
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
SMG-1 is a phosphatidylinosito ...... ecay in Caenorhabditis elegans
@en
SMG-1 is a phosphatidylinosito ...... cay in Caenorhabditis elegans.
@nl
type
label
SMG-1 is a phosphatidylinosito ...... ecay in Caenorhabditis elegans
@en
SMG-1 is a phosphatidylinosito ...... cay in Caenorhabditis elegans.
@nl
prefLabel
SMG-1 is a phosphatidylinosito ...... ecay in Caenorhabditis elegans
@en
SMG-1 is a phosphatidylinosito ...... cay in Caenorhabditis elegans.
@nl
P2093
P2860
P1476
SMG-1 is a phosphatidylinosito ...... ecay in Caenorhabditis elegans
@en
P2093
Andrew Grimson
Carrie Loushin Newman
Philip Anderson
Sean O'Connor
P2860
P304
P356
10.1128/MCB.24.17.7483-7490.2004
P407
P577
2004-09-01T00:00:00Z