Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.
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And-1 is required for the stability of histone acetyltransferase Gcn5Influence of the human cohesion establishment factor Ctf4/AND-1 on DNA replicationThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationHow do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?RECQL4 in genomic instability and agingStructure of a DNA Polymerase -Primase Domain That Docks on the SV40 Helicase and Activates the Viral PrimosomeSolution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 Reveals a Conserved MCM MotifMcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil DomainThe N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motifRecQ helicases in DNA double strand break repair and telomere maintenance.Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknownsThe replication initiation protein Sld2 regulates helicase assembly.An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication InitiationThe structural basis for MCM2-7 helicase activation by GINS and Cdc45.Initiation of replication in Xenopus egg extracts at a spatially defined originRecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cellsAcidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres.Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMThe involvement of human RECQL4 in DNA double-strand break repair.And-1 is required for homologous recombination repair by regulating DNA end resection.Cdc45-induced loading of human RPA onto single-stranded DNA.And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenanceImpaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiationInitiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs.Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression.Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells.Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy.MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity.Drosophila RecQ4 is directly involved in both DNA replication and the response to UV damage in S2 cells.The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patientsRECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.Human RecQL4 helicase plays critical roles in prostate carcinogenesis.Over expression of minichromosome maintenance genes is clinically correlated to cervical carcinogenesis.RecQL4 helicase amplification is involved in human breast tumorigenesis.Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.Borrowing nuclear DNA helicases to protect mitochondrial DNA.The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase.Mcm10 coordinates the timely assembly and activation of the replication fork helicase.
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Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@en
Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@nl
type
label
Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@en
Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@nl
prefLabel
Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@en
Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@nl
P2093
P2860
P356
P1476
Assembly of the Cdc45-Mcm2-7-G ...... 1, RecQL4, and Mcm10 proteins.
@en
P2093
Andrea Farina
Dong-Soo Jung
Jerard Hurwitz
Joon-Kyu Lee
Jun-Sub Im
Sang-Hee Ki
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P304
15628-15632
P356
10.1073/PNAS.0908039106
P407
P577
2009-09-08T00:00:00Z