about
PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2NMR-assignments of a cytosolic domain of the C-terminus of polycystin-2TRPP2 channel regulationAltered expression pattern of polycystin-2 in acute and chronic renal tubular diseasesLack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal ciliaLMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome.Advanced electron microscopic techniques provide a deeper insight into the peculiar features of podocytes.Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.Polycystin-2--an intracellular or plasma membrane channel?New developments in the field of cystic kidney diseases.Intravital Imaging Reveals Angiotensin II-Induced Transcytosis of Albumin by Podocytes.Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.A mammalian expression vector for the expression of GAL4 fusion proteins with an epitope tag and histidine tail.Identification and characterization of polycystin-2, the PKD2 gene product.Biodistribution of quantum dots in the kidney after intravenous injection.Kidney podocytes as specific targets for cyclo(RGDfC)-modified nanoparticles.Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells.ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells.Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells.Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells.Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance.Polycystin-2 takes different routes to the somatic and ciliary plasma membrane.Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.The rat pkd2 protein assumes distinct subcellular distributions in different organs.Photochemically Active Fluorophore-DNA/RNA Conjugates for Cellular Imaging of Nucleic Acids by Readout in Electron Microscopy.Soluble interleukin-2 receptors inhibit interleukin 2-dependent proliferation and cytotoxicity: explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo?How are podocytes affected in nail-patella syndrome?Up-regulation of the human serum and glucocorticoid-dependent kinase 1 in glomerulonephritis.Use of the tetracycline system for inducible protein synthesis in the kidney.Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease.The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.Nonspecific cation current associated with native polycystin-2 in HEK-293 cells.Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains.
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description
hulumtues
@sq
researcher
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ricercatore
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wetenschapper
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հետազոտող
@hy
name
Ralph Witzgall
@ast
Ralph Witzgall
@en
Ralph Witzgall
@es
Ralph Witzgall
@nl
Ralph Witzgall
@sl
type
label
Ralph Witzgall
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Ralph Witzgall
@en
Ralph Witzgall
@es
Ralph Witzgall
@nl
Ralph Witzgall
@sl
prefLabel
Ralph Witzgall
@ast
Ralph Witzgall
@en
Ralph Witzgall
@es
Ralph Witzgall
@nl
Ralph Witzgall
@sl
P106
P21
P214
58145971452032331636
P31
P496
0000-0002-5283-4846
P735
P7859
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