Conversion of human choriogonadotropin into a follitropin by protein engineering.
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Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsIn silico study on binding specificity of gonadotropins and their receptors: design of a novel and selective peptidomimetic for human follicle stimulating hormone receptor.Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit.Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones.The groove between the alpha- and beta-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding.Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.Model of glycoprotein hormone receptor ligand binding and signaling.Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes.Glycoprotein hormone assembly in the endoplasmic reticulum: I. The glycosylated end of human alpha-subunit loop 2 is threaded through a beta-subunit hole.Human lutropin (hLH) and choriogonadotropin (CG) are assembled by different pathways: a model of hLH assembly.Oligosaccharides containing beta 1,4-linked N-acetylgalactosamine, a paradigm for protein-specific glycosylation.Molecular cloning and characterization of pirarucu (Arapaima gigas) follicle-stimulating hormone and luteinizing hormone β-subunit cDNAs.Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.Lutropins appear to contact two independent sites in the extracellular domain of their receptors.Follitropin receptors contain cryptic ligand binding sites.Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity.Glycoprotein hormone assembly in the endoplasmic reticulum: III. The seatbelt and its latch site determine the assembly pathway.Glycoprotein hormone assembly in the endoplasmic reticulum: II. Multiple roles of a redox sensitive beta-subunit disulfide switch.
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Conversion of human choriogonadotropin into a follitropin by protein engineering.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on February 1991
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conversion of human choriogonadotropin into a follitropin by protein engineering.
@en
Conversion of human choriogonadotropin into a follitropin by protein engineering.
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label
Conversion of human choriogonadotropin into a follitropin by protein engineering.
@en
Conversion of human choriogonadotropin into a follitropin by protein engineering.
@nl
prefLabel
Conversion of human choriogonadotropin into a follitropin by protein engineering.
@en
Conversion of human choriogonadotropin into a follitropin by protein engineering.
@nl
P2093
P2860
P356
P1476
Conversion of human choriogonadotropin into a follitropin by protein engineering.
@en
P2093
D M Dean-Emig
R K Campbell
P2860
P304
P356
10.1073/PNAS.88.3.760
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P577
1991-02-01T00:00:00Z