Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones.
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Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsSolution structure of the alpha-subunit of human chorionic gonadotropinAssessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information.Hormone interactions to Leu-rich repeats in the gonadotropin receptors. I. Analysis of Leu-rich repeats of human luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor.The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation.Ligand-induced receptor dimerization may be critical for signal transduction by choriogonadotropin.The antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants.Structure-function relationships of the luteinizing hormone receptor.A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.The groove between the alpha- and beta-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding.Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.Model of glycoprotein hormone receptor ligand binding and signaling.Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes.Engineering human glycoprotein hormone superactive analogues.Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity.Delineation of regions in the extracellular domain of follicle-stimulating hormone receptor involved in hormone binding and signal transduction.Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.The rate of internalization of the gonadotropin receptors is greatly affected by the origin of the extracellular domain.Fertility-disrupting potential of synthetic peptides derived from the beta-subunit of follicle-stimulating hormone.Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation.Protein engineering of a novel constitutively active hormone-receptor complex.Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region.Hormone-induced conformational change of the purified soluble hormone binding domain of follitropin receptor complexed with single chain follitropin.Lutropins appear to contact two independent sites in the extracellular domain of their receptors.Hormone interactions to Leu-rich repeats in the gonadotropin receptors. II. Analysis of Leu-rich repeat 4 of human luteinizing hormone/chorionic gonadotropin receptor.Autologous biological response modification of the gonadotropin receptor.Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity.Glycoprotein hormone assembly in the endoplasmic reticulum: II. Multiple roles of a redox sensitive beta-subunit disulfide switch.Super hormones.Hetero-oligomerization-dependent binding of pig oocyte zona pellucida glycoproteins ZPB and ZPC to boar sperm membrane vesicles.
P2860
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P2860
Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Model of human chorionic gonad ...... of the glycoprotein hormones.
@en
type
label
Model of human chorionic gonad ...... of the glycoprotein hormones.
@en
prefLabel
Model of human chorionic gonad ...... of the glycoprotein hormones.
@en
P2093
P2860
P356
P1476
Model of human chorionic gonad ...... of the glycoprotein hormones.
@en
P2093
Bernard MP
Campbell RK
P2860
P304
20020-20031
P356
10.1074/JBC.270.34.20020
P407
P577
1995-08-01T00:00:00Z