Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. - Wikidata - wikimedia - TriplyDB

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

http://www.wikidata.org/entity/Q37415334

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Molecular insight into substrate recognition by human cytosolic sialidase NEU2 CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts Allosteric Modulation of Chemoattractant Receptors CXCR2: a target for pancreatic cancer treatment?A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis Targeting CXCR1/CXCR2 receptor antagonism in malignant melanoma The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Leu128(3.43) (l128) and Val247(6.40) (V247) of CXCR1 are critical amino acid residues for g protein coupling and receptor activation.Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism.CXCR1/2 pathways in paclitaxel-induced neuropathic pain The dominant role of IL-8 as an angiogenic driver in a three-dimensional physiological tumor construct for drug testing.Inhibition of CXCR1 and CXCR2 chemokine receptors attenuates acute inflammation, preserves gray matter and diminishes autonomic dysreflexia after spinal cord injury.RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects Targeting IL-8 in colorectal cancer.Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases.Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2 Small-molecule antagonists for CXCR2 and CXCR1 inhibit human melanoma growth by decreasing tumor cell proliferation, survival, and angiogenesis MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development.Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury.A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling.Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer.The interleukin-8 (IL-8/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats.Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration.Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.Chemokines: integrators of pain and inflammation.CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats.Therapeutic targeting of molecules involved in leukocyte-endothelial cell interactions.Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice Reparixin, a CXCR1/2 inhibitor in islet allotransplantation.

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P2860

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

http://www.wikidata.org/entity/Q37415334

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 28 July 2004

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Noncompetitive allosteric inhi ...... vention of reperfusion injury.

@en

Noncompetitive allosteric inhi ...... vention of reperfusion injury.

@nl

type

label

Noncompetitive allosteric inhi ...... vention of reperfusion injury.

@en

Noncompetitive allosteric inhi ...... vention of reperfusion injury.

@nl

prefLabel

Noncompetitive allosteric inhi ...... vention of reperfusion injury.

@en

Noncompetitive allosteric inhi ...... vention of reperfusion injury.

@nl

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PNAS.0402090101

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Proceedings of the National Academy of Sciences of the United States of America

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Noncompetitive allosteric inhi ...... evention of reperfusion injury

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Alessio Moriconi

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Angela Santoni

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Barbara Cavalieri

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Cinzia Bizzarri

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Emanuela Galliera

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Fernando O Martinez

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Franck Martin

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Gaetano D'Anniballe

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Giulia Troiani

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Giuseppe Poli

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2004-07-28T00:00:00Z

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15282370

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reperfusion injury

allosteric inhibitor

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