Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node.
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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growthExercise Regulation of Marrow Adipose TissueGap junctional regulation of signal transduction in bone cellsCell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed NucleusTreadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized ratsMechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cellsBone marrow fat accumulation accelerated by high fat diet is suppressed by exercise.Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.Arginine enhances osteoblastogenesis and inhibits adipogenesis through the regulation of Wnt and NFATc signaling in human mesenchymal stem cells.Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in boneDeletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loadingExercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice.Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress.Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen.Activation of β-catenin signalling leads to temporomandibular joint defects.Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells.Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiationEffect of silver nanoparticles on human mesenchymal stem cell differentiation.Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.The pathogenesis of COPD and IPF: distinct horns of the same devil?Mechanical regulation of signaling pathways in bone.Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer.Substrate nanotexture and hypergravity through centrifugation enhance initial osteoblastogenesis.Biomechanical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor.Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality.Steady and oscillatory fluid flows produce a similar osteogenic phenotype.Effect of the harvest procedure and tissue site on the osteogenic function of and gene expression in human mesenchymal stem cells.Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineagemTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells.Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton.Mechanosignaling in bone health, trauma and inflammation.Mechanical Stress Regulates Osteogenesis and Adipogenesis of Rat Mesenchymal Stem Cells through PI3K/Akt/GSK-3β/β-Catenin Signaling Pathway.GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.Stem cells for tendon tissue engineering and regeneration.Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury.Beta-catenin--a supporting role in the skeleton.
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Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mechanical loading regulates N ...... rough a GSK3beta control node.
@en
Mechanical loading regulates N ...... rough a GSK3beta control node.
@nl
type
label
Mechanical loading regulates N ...... rough a GSK3beta control node.
@en
Mechanical loading regulates N ...... rough a GSK3beta control node.
@nl
prefLabel
Mechanical loading regulates N ...... rough a GSK3beta control node.
@en
Mechanical loading regulates N ...... rough a GSK3beta control node.
@nl
P2093
P2860
P356
P1476
Mechanical loading regulates N ...... rough a GSK3beta control node.
@en
P2093
Clinton T Rubin
Janet Rubin
Maya Styner
Natasha Case
Zhihui Xie
P2860
P304
34607-34617
P356
10.1074/JBC.M109.039453
P407
P577
2009-10-19T00:00:00Z