Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes - Wikidata - wikimedia - TriplyDB

Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes

Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes

http://www.wikidata.org/entity/Q37454290

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Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane Cytokine profiling in patients with VCP-associated disease.Enzymatic blockade of the ubiquitin-proteasome pathway Cholesterol, the central lipid of mammalian cells Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol.Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis Scap is required for sterol synthesis and crypt growth in intestinal mucosa.Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin.Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi Regulation of cholesterol and fatty acid synthesis.Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response.Perturbation of Intracellular Cholesterol and Fatty Acid Homeostasis During Flavivirus Infections.

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Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes

http://www.wikidata.org/entity/Q37454290

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 08 October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Regulated endoplasmic reticulu ...... fore extraction from membranes

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Regulated endoplasmic reticulu ...... ore extraction from membranes.

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type

label

Regulated endoplasmic reticulu ...... fore extraction from membranes

@en

Regulated endoplasmic reticulu ...... ore extraction from membranes.

@nl

prefLabel

Regulated endoplasmic reticulu ...... fore extraction from membranes

@en

Regulated endoplasmic reticulu ...... ore extraction from membranes.

@nl

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JBC.M109.044875

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Journal of Biological Chemistry

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Regulated endoplasmic reticulu ...... fore extraction from membranes

@en

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George N Demartino

http://www.w3.org/2001/XMLSchema#string

Jin Ye

http://www.w3.org/2001/XMLSchema#string

Joon No Lee

http://www.w3.org/2001/XMLSchema#string

Michael S Brown

http://www.w3.org/2001/XMLSchema#string

Yukio Ikeda

http://www.w3.org/2001/XMLSchema#string

P2860

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

One step at a time: endoplasmic reticulum-associated degradation

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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34889-34900

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scholarly article

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10.1074/JBC.M109.044875

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P433

50

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284

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Joseph L. Goldstein

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2009-10-08T00:00:00Z

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26881523

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19815544

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endoplasmic reticulum

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2787351

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