Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.
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Matrix crosslinking forces tumor progression by enhancing integrin signalingSelective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal CancerNBR1 enables autophagy-dependent focal adhesion turnoverBiochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decadeNo effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancerMultiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomicsAngiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9.A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions.Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progressionDisruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer.Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects.Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer.Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathwaysDrug-target residence time: critical information for lead optimization.An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment.Matrix metalloproteinases in tumorigenesis: an evolving paradigm.Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment.Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo.Direct transformation of lung microenvironment by interferon-α treatment counteracts growth of lung metastasis of hepatocellular carcinoma.Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines.Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinasesUnimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor.Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review.Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancerDown-regulation of Gab1 inhibits cell proliferation and migration in hilar cholangiocarcinomaFunctional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation.Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases.Selective water-soluble gelatinase inhibitor prodrugs.Presence of insulin-like growth factor binding proteins correlates with tumor-promoting effects of matrix metalloproteinase 9 in breast cancer.Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence.Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptorNew tools for the quantitative assessment of prodrug delivery and neurotoxicity.Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors
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P2860
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Effect of ablation or inhibiti ...... pendent on genetic background.
@en
Effect of ablation or inhibiti ...... pendent on genetic background.
@nl
type
label
Effect of ablation or inhibiti ...... pendent on genetic background.
@en
Effect of ablation or inhibiti ...... pendent on genetic background.
@nl
prefLabel
Effect of ablation or inhibiti ...... pendent on genetic background.
@en
Effect of ablation or inhibiti ...... pendent on genetic background.
@nl
P2093
P2860
P1433
P1476
Effect of ablation or inhibiti ...... pendent on genetic background.
@en
P2093
Barbara Fingleton
Conor C Lynch
Kathy J Carter
Lynn M Matrisian
Mayland Chang
Michelle D Martin
Shahriar Mobashery
Sharon R Jean-Philippe
Sophie Thiolloy
P2860
P304
P356
10.1158/0008-5472.CAN-08-0537
P407
P577
2008-08-01T00:00:00Z