Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. - Wikidata - wikimedia - TriplyDB

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

http://www.wikidata.org/entity/Q37474395

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Cancer pharmacogenomics: strategies and challenges Acute lymphoblastic leukaemia Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics Systems pharmacology: network analysis to identify multiscale mechanisms of drug action Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy A health-care system perspective on implementing genomic medicine: pediatric acute lymphoblastic leukemia as a paradigm Pharmacogenomics of breast cancer therapy: an update Pharmacogenomics of chemotherapeutic susceptibility and toxicity Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use Pharmacogenetics predictive of response and toxicity in acute lymphoblastic leukemia therapy Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver Leukoencephalopathy due to oral methotrexate Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs Pharmacogenetics of microRNAs and microRNAs biogenesis machinery in pediatric acute lymphoblastic leukemia Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.Non-infectious chemotherapy-associated acute toxicities during childhood acute lymphoblastic leukemia therapy.The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.Polymorphisms in folate pathway and pemetrexed treatment outcome in patients with malignant pleural mesothelioma.Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia.Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance.Implementation and utilization of genetic testing in personalized medicine.A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required.SLC19A1 pharmacogenomics summary.Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.Pharmacogenomics and individualized medicine: translating science into practice.The intestinal absorption of folates.Genome-wide association studies in pharmacogenomics: successes and lessons.Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia.Biology, risk stratification, and therapy of pediatric acute leukemias: an update.Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections.SLCO1B1 and SLC19A1 gene variants and irinotecan-induced rapid response and survival: a prospective multicenter pharmacogenetics study of metastatic colorectal cancer PharmGKB summary: methotrexate pathway.Association of CYP2D6*10, OATP1B1 A388G, and OATP1B1 T521C polymorphisms and overall survival of breast cancer patients after tamoxifen therapy The physiological role of drug transporters.Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease.Functional characterization of liver enhancers that regulate drug-associated transporters.Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

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P2860

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

http://www.wikidata.org/entity/Q37474395

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Germline genetic variation in ...... kinetics and clinical effects.

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Journal of Clinical Oncology

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Germline genetic variation in ...... kinetics and clinical effects.

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Cheng Cheng

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Deqing Pei

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Diana Chan

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John C Panetta

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Kathleen M Giacomini

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Lisa R Treviño

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Mary V Relling

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Noriko Shimasaki

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Wenjian Yang

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William E Evans

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P2860

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase

Treating childhood acute lymphoblastic leukemia without cranial irradiation

A common allele on chromosome 9 associated with coronary heart disease

Genomewide association analysis of coronary artery disease

Principal components analysis corrects for stratification in genome-wide association studies

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

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Alex Sparreboom

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