Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.
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SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stabilityTranslational development of difluoromethylornithine (DFMO) for the treatment of neuroblastomaChemoresistance, cancer stem cells, and miRNA influences: the case for neuroblastomaTumors of the neural crest: Common themes in development and cancerInvolvement of midkine in neuroblastoma tumourigenesisTherapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.The zebrafish as a model for studying neuroblastomaNeuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology.Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.The prenatal origins of cancerDidymin: an orally active citrus flavonoid for targeting neuroblastoma.The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.Preclinical models for neuroblastoma: establishing a baseline for treatmentMalignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cellsCiliary neurotrophic factor reduces the proliferation and promotes the differentiation of TH- MYCN transformed sympathoadrenal progenitors.CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients.Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma.Generation of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands.ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenicNucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents.Neuroblastoma: molecular pathogenesis and therapy.An unexpected role for caspase-2 in neuroblastoma.Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis.MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation.Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development.A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastomaActivation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.Enhancing the anti-angiogenic action of histone deacetylase inhibitors.Redefining functional MYCN gene signatures in neuroblastoma.Molecular imaging of neuroblastoma progression in TH-MYCN transgenic mice.TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localizationThe mTOR pathway negatively controls ATM by up-regulating miRNAs.Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivoMYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development
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Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 August 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mechanisms of embryonal tumor ...... ession and MYCN amplification.
@en
Mechanisms of embryonal tumor ...... ession and MYCN amplification.
@nl
type
label
Mechanisms of embryonal tumor ...... ession and MYCN amplification.
@en
Mechanisms of embryonal tumor ...... ession and MYCN amplification.
@nl
prefLabel
Mechanisms of embryonal tumor ...... ession and MYCN amplification.
@en
Mechanisms of embryonal tumor ...... ession and MYCN amplification.
@nl
P2093
P2860
P50
P356
P1476
Mechanisms of embryonal tumor ...... ression and MYCN amplification
@en
P2093
Catherine A Burkhart
Glenn M Marshall
Joanna M Keating
Loen M Hansford
Patricia J Armati
Wayne D Thomas
P2860
P304
12664-12669
P356
10.1073/PNAS.0401083101
P407
P577
2004-08-16T00:00:00Z