YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.
about
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significancePhosphoinositides: tiny lipids with giant impact on cell regulationPI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathiesThe PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cellsPIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signalingMuscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switchingThe phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infectionGenetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responsesSac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytesClass III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasisPtdIns5P: news and views of its appearance, disappearance and deeds.Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate.Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.PI3K signaling: a crossroads of metabolic regulationApilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation
P2860
Q24615140-4A50574D-18FE-4D83-AFDD-002CBFD4E748Q24620024-BDEAFA99-1DE1-4F0C-A313-E8C745213984Q26823539-B9FFF8FB-1A79-4656-9336-006C67F379E7Q27012953-4993FFD3-A39D-4FE5-B67C-8402569B9FD4Q27310309-BB05A65F-6849-4107-950D-59DFAD83D34BQ28477563-95028B5F-A5CA-46B9-902B-016C6A89911BQ28481359-A62C5FC2-89F1-43C0-B331-390C0C3B7AE6Q28833590-4062F789-2270-4B59-8EBF-6DB53C4C55A7Q29035970-005700FC-F314-43C1-94DB-70C85A09FC01Q30252649-615F42AC-A75A-42D1-B2AA-ED98C8CD8F52Q30560982-BF9B5869-25A9-42DB-ACD4-9490A4C715E4Q30608508-A5CB0EB8-C7ED-4BB0-8BFA-A3AEA0F13B85Q34526188-A78D4B79-84AB-4CAB-BCC0-7F399F1A577CQ34989470-D4243300-5731-491C-B804-5D2081DE8BEFQ34990714-4B7FCC0E-B435-4E5C-A538-22A4C0E5307AQ35606052-8FB9961C-20BA-4726-A135-BC1C5E8DEE85Q35763394-662B4B6A-9E7D-4451-ACCD-7C798115B78BQ36257177-AC9BF784-C706-42D9-9944-D13957B27171Q37005875-009D8815-C159-4CD6-B4B3-74B6AE2B5F91Q37898748-3EE63782-16A6-4CAA-9F2B-19361CA82500Q38174542-5A1B2C62-3C05-471E-A727-B56447BB11A3Q38422343-221F547A-020D-4C8F-82C5-7B51714794F2Q38936250-4A8E4753-44E5-4C0B-8E66-5930838FF093Q38973926-845ABB1A-F4AD-462D-A1F9-07A386FC9A57Q39117162-079EB5C4-4A46-4EE7-9DE9-57B15A72FC28Q40105885-47DA368E-CF70-45A6-A8E0-EB58C5FD0AE0Q43694028-B941AF58-DBF2-46A4-83A3-3CA92F706EEEQ52584739-AF674F0F-C09B-49E7-ACDA-39CB64A53BEFQ57006161-7A19AF9F-13F9-46D2-AA31-9BC6008980ECQ58707196-BC21EAA6-E1F5-4592-8450-5FADDF0425A0
P2860
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@en
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@nl
type
label
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@en
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@nl
prefLabel
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@en
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@nl
P2093
P2860
P921
P1476
YM201636, an inhibitor of retr ...... ntry by insulin in adipocytes.
@en
P2093
Assia Shisheva
Diego Sbrissa
Ognian C Ikonomov
P2860
P304
P356
10.1016/J.BBRC.2009.03.063
P407
P577
2009-03-14T00:00:00Z