Molecular pathogenesis of Parkinson disease: insights from genetic studies.
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Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismPhosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionIdentification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycleUntangling the Manganese-α-Synuclein WebStriatal cholinergic interneuron regulation and circuit effectsThe regulation and deregulation of Wnt signaling by PARK genes in health and diseaseAutophagy in the physiology and pathology of the central nervous systemHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsLoss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15)The importance of Wnt signalling for neurodegeneration in Parkinson's diseaseStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsVPS35 regulates cell surface recycling and signaling of dopamine receptor D1α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's diseaseαβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunctionDrosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusinRole of Rab GTPases in membrane traffic and cell physiologyMechanisms underlying inflammation in neurodegenerationBcl-2 homologue Debcl enhances α-synuclein-induced phenotypes in Drosophila.The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.Stem cell-based models and therapies for neurodegenerative diseasesAutophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death.A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Parkinson's disease: insights from pathways.Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death.Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeysNatural toxins implicated in the development of Parkinson's disease.Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.LRRK2 function on actin and microtubule dynamics in Parkinson diseaseDJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death.PET analysis of dopaminergic neurodegeneration in relation to immobility in the MPTP-treated common marmoset, a model for Parkinson's disease.Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment.Modeling mitochondrial dysfunctions in the brain: from mice to men.Meta-Analysis of Parkinson's Disease Transcriptome Data Using TRAM Software: Whole Substantia Nigra Tissue and Single Dopamine Neuron Differential Gene Expression.
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Molecular pathogenesis of Parkinson disease: insights from genetic studies.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@en
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@nl
type
label
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@en
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@nl
prefLabel
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@en
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@nl
P2860
P1476
Molecular pathogenesis of Parkinson disease: insights from genetic studies.
@en
P2860
P356
10.1017/S1462399409001148
P577
2009-07-27T00:00:00Z